Accessible Requires Authentication Published by Oldenbourg Wissenschaftsverlag April 16, 2010

Radiosynthesis and evaluation of [61Cu]-9,10-phenanthrenequinone thiosemicarbazone in fibrosarcoma-bearing animals for PET imaging

A. R. Jalilian, Azamolsadat Emami, M. Akhlaghi, M. Kamali-dehghan, Kamaledin Shafaii and Sedigheh Moradkhani
From the journal rca - Radiochimica Acta

Abstract

[61Cu]-9,10-Phenanthrenequinone thiosemicarbazone ( 61Cu-PQTS), a radiolabeled anticancer compound was prepared for malignant tissue imaging studies. Copper-61 was produced via the natZn(px) 61Cu nuclear reaction in a 30 MeV cyclotron (150 μA irradiation for 76 min, radionuclidic purity >95%). 61Cu-PQTS was prepared from in-house synthesized PQTS. Quality control was performed using ITLC. The biodistribution of the tracer was compared to the biodistribution of cationic copper-61 in healthy controls. 61Cu-PQTS was then administered to fibrosarcoma-bearing mice for biodistribution and co-incidence imaging studies. 61Cu-PQTS demonstrated significant tumor uptake of 2.1% ID/g and the tumor was clearly visualized in a fibrosarcoma model.


* Correspondence address: Nuclear Medicine Research Group, Agricultural,, Medical and Industrial Research School (AMIRS), P.O. Box 31485-4395, Karaj, Iran,

Published Online: 2010-04-16
Published in Print: 2010-03

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