Accessible Requires Authentication Published by Oldenbourg Wissenschaftsverlag September 25, 2009

A no-carrier-added 72Se/72As radionuclide generator based on distillation

M. Jennewein, A. Schmidt, A. F. Novgorodov, Syed M. Qaim and Frank Rösch
From the journal Radiochimica Acta

Abstract

Arsenic-72 is a positron emitting isotope with promising properties for syntheses of 72As-labelled radiopharmaceuticals for future application in positron emission tomography. This work describes the radiochemical separation of no-carrier-added 72Se from cyclotron irradiated germanium targets and the development of a 72Se/72As radionuclide generator, avoiding the addition of any selenium carrier. Using a vertical quartz tube device, no-carrier-added 72As is nearly quantitatively released from various chloride salt solutions containing 72Se within 10 min at a temperature of 100 °C in an HCl gas flow. The kinetics of the 72Se/72As isotope generator has been studied in relation to temperature, salt charge, and redox-stability. Under optimised conditions, 72Se remains almost quantitatively (>99.7%) in solution.

Published Online: 2009-9-25
Published in Print: 2004-4-1

© 2004 Oldenbourg Wissenschaftsverlag GmbH