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Publicly Available Published by De Gruyter (O) April 16, 2010

The strong phase object approximation may allow extending crystallographic phases of dynamical electron diffraction patterns of 3D protein nano-crystals

  • Jan Pieter Abrahams

Abstract

Simulations suggest that the strong phase object approximation of dynamical scattering may allow extracting crystallographic phase information from single 2D electron diffraction patterns of 3D protein crystals using probabilitistic procedures. Unlike other phasing methods, the procedure does not requires any additional knowledge – like real space images, atomicity, non-crystallographic symmetry, the presence or location of disordered solvent or the availability of a support with a known structure. In specific cases, the availability of precession electron diffraction data can further improve the phases.


* Correspondence address: Leiden Institute of Chemistry, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, Niederlande,

Published Online: 2010-04-16
Published in Print: 2010-03

© by Oldenbourg Wissenschaftsverlag, München, Germany

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