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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) September 25, 2009

Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

  • Christoph Alexiou , Roland Jurgons , Christian Seliger , Sabine Kolb , Bernd Heubeck and Heinrich Iro
From the journal Zeitschrift für Physikalische Chemie
https://doi.org/10.1524/zpch.2006.220.2.235

Summary

Magnetic drug targeting (MDT) is a new approach in local cancer therapy. Starch coated magnetite nanoparticles bound to the chemotherapeutic agent mitoxantrone can be enriched in the tumor region of a VX2 squamous cell carcinoma in rabbits. Using fluorescence-microscopy we showed enrichment of the chemotherapeutic agent in its site of action, the DNA.

Keywords: Drug Targeting; Local Chemotherapy; Magnetic Nanoparticles; Magnetic Field
Received: 2005-9-19
Accepted: 2005-10-28
Published Online: 2009-9-25
Published in Print: 2006-2-1

© by Oldenbourg Wissenschaftsverlag, München

From the journal
Zeitschrift für Physikalische Chemie
Zeitschrift für Physikalische Chemie
Volume 220 Issue 2
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Journal and Issue

Articles in the same Issue

Magnetic Nanoparticles for Biomedical Heating Applications
Characterization of the Grain Size in Ferromagnetic Colloids: Comparing Torsional-Pendulum Measurements with Standard Complementary Methods
Structural and Magnetic Properties of Ni/NiOxide- and Co/CoOxide Core/Shell Nanoparticles and their possible Use for Ferrofluids
Nanoscaled Nickel-Zinc-Iron Oxides of Spinell Type as Soft Magnetic Colloids and their Ferromagnetic Resonance Spectrum
Gravity Level Influence on a Laterally Heated Ferrofluid Submitted to an Oblique Strong Magnetic Field
Determination of the Thermo and Magneto Phoresis by the Dissipative Function
Magnetization of Rotating Ferrofluids: Predictions of Different Theoretical Models
Thermal Ratchet Effect in a Rotating Ferrofluid
Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells
Some Immobilization Modes of Biologically Active Substances to Fine Magnetic Particles
On Magnetic Field Control Experiments of Ferrofluid Convection Motion
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