Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter (O) September 25, 2009

Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

Christoph Alexiou , Roland Jurgons , Christian Seliger , Sabine Kolb , Bernd Heubeck and Heinrich Iro

Summary

Magnetic drug targeting (MDT) is a new approach in local cancer therapy. Starch coated magnetite nanoparticles bound to the chemotherapeutic agent mitoxantrone can be enriched in the tumor region of a VX2 squamous cell carcinoma in rabbits. Using fluorescence-microscopy we showed enrichment of the chemotherapeutic agent in its site of action, the DNA.

Received: 2005-9-19
Accepted: 2005-10-28
Published Online: 2009-9-25
Published in Print: 2006-2-1

© by Oldenbourg Wissenschaftsverlag, München

Downloaded on 28.1.2023 from https://www.degruyter.com/document/doi/10.1524/zpch.2006.220.2.235/html
Scroll Up Arrow