Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

Christoph Alexiou; Roland Jurgons; Christian Seliger; Sabine Kolb; Bernd Heubeck; Heinrich Iro

doi:10.1524/zpch.2006.220.2.235

Published by De Gruyter (O) September 25, 2009

Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

Christoph Alexiou

, Roland Jurgons

, Christian Seliger

, Sabine Kolb

, Bernd Heubeck

and Heinrich Iro

From the journal Zeitschrift für Physikalische Chemie

https://doi.org/10.1524/zpch.2006.220.2.235

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Summary

Magnetic drug targeting (MDT) is a new approach in local cancer therapy. Starch coated magnetite nanoparticles bound to the chemotherapeutic agent mitoxantrone can be enriched in the tumor region of a VX2 squamous cell carcinoma in rabbits. Using fluorescence-microscopy we showed enrichment of the chemotherapeutic agent in its site of action, the DNA.

Keywords: Drug Targeting; Local Chemotherapy; Magnetic Nanoparticles; Magnetic Field

Received: 2005-9-19

Accepted: 2005-10-28

Published Online: 2009-9-25

Published in Print: 2006-2-1

Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

Summary

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