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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) September 25, 2009

Distribution of Mitoxantrone after Magnetic Drug Targeting: Fluorescence Microscopic Investigations on VX2 Squamous Cell Carcinoma Cells

  • Christoph Alexiou , Roland Jurgons , Christian Seliger , Sabine Kolb , Bernd Heubeck and Heinrich Iro


Magnetic drug targeting (MDT) is a new approach in local cancer therapy. Starch coated magnetite nanoparticles bound to the chemotherapeutic agent mitoxantrone can be enriched in the tumor region of a VX2 squamous cell carcinoma in rabbits. Using fluorescence-microscopy we showed enrichment of the chemotherapeutic agent in its site of action, the DNA.

Received: 2005-9-19
Accepted: 2005-10-28
Published Online: 2009-9-25
Published in Print: 2006-2-1

© by Oldenbourg Wissenschaftsverlag, München

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