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Licensed Unlicensed Requires Authentication Published by De Gruyter February 28, 2018

Biodegradabiliy of spherical mesoporous silica particles (MCM-41) in simulated body fluid (SBF)

Elena Boccardi, Anahì Philippart, Ana M. Beltrán, Jochen Schmidt, Liliana Liverani, Wolfgang Peukert and Aldo R. Boccaccini
From the journal American Mineralogist

Abstract

Mesoporous silica particles of type MCM-41 (Mobile Composition of Matter No. 41), exhibiting highly ordered mesoporosity (pores with diameter between 2 and 50 nm) and surface roughness, are developed and used as a functional coating on bioactive glass-based scaffolds for bone tissue engineering. The degradability and the mesostructure stability of these novel MCM-41 particles were evaluated. The particles are immersed in simulated body fluid (SBF) for up to 28 days at 37 °C, and the variation of the ordered porosity, surface characteristics, and chemical composition of the particles are assessed by SEM-EDX, HRTEM, FTIR, ICP-OES, and pH measurements. The results indicate that the MCM-41 particles are affected by immersion in SBF only during the first few days; however, the surface and the mesopore structure of the particles do not change further with increasing time in SBF. The pore channel diameter increased slightly, confirming the stability of the developed material. The release of dissolved Si-species, which reached a maximum of 260 mg SiO2 per gram of material, could play a key role in gene activation of osteoblast cells and in inducing new bone matrix formation.


† Current address: Departamento de Ingeniería y Ciencia de los Materiales y del Transporte Universidad de Sevilla, 41092 Seville, Spain

† Special collection papers can be found online at http://www.minsocam.org/MSA/AmMin/special-collections.html.


Acknowledgments

Liliana Liverani acknowledges funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement no. 657264. Ana M. Beltrán thanks Talent-Hub Program funded by the Junta de Andalucía and the European Commission under the Co-funding of the 7th Framework Program in the People Program (Marie Curie Special Action). The authors also acknowledge the Laboratory for Nanoscopies and Spectroscopies (LANE) at the ICMS (Consejo Superior de Investigaciones Científicas) for use of their TEM facilities.

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Received: 2017-8-22
Accepted: 2017-11-19
Published Online: 2018-2-28
Published in Print: 2018-3-26

© 2018 Walter de Gruyter GmbH, Berlin/Boston

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