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Licensed Unlicensed Requires Authentication Published by De Gruyter November 26, 2007

Ginger Modulates Lymphocyte Activity in Vitro and in Vivo and Modestly Prolongs Cardiac Allograft Survival

Chumpon Wilasrusmee, Smita Kittur, Sudipta Tripathi, Gaurang Shah, David Bruch and Dilip S Kittur

Objectives: Ginger, an herb with diverse pharmacotherapeutic properties, is used as an anti-inflammatory agent in immunological disorders like rheumatoid arthritis. The objective of the present investigation was to study the effect of ginger on alloreactivity and on prolongation of cardiac allograft in mice.Design: We tested the effect of ginger extract on lymphocytes in vitro and in vivo and the response of ginger treated lymphocytes to allostimulation and cytosine release. We also studied the effect of ginger extract on cardiac allograft survival in a non vascularized transplantation model in mice.Results: We observed an immunosuppressive effect of ginger in vitro and in vivo. Ginger extract decreased lymphocyte proliferation in response to allostimulation. Ginger extract also decreased the production of the immunostimulatory cytokines IL-2, IL-4 and IFN-? and increased the production of the immunomudulatory cytokines IL-10 and TGF?1. Ginger extract by itself produced a modest increase in the survival of cardiac allografts in mice survival.Conclusion: Our study demonstrates that ginger extract has immunosuppressive effects both in vitro on lymphocyte proliferation and cytokine production and in vivo on allograft survival.

Published Online: 2007-11-26

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston

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