Objectives: The aim of the present study was to evaluate the radioprotective effect of Grewia asiatica fruit pulp extract (GAE) on Swiss albino mice against radiation induced hematological and biochemical alterations. Experimental Design: Mice (6–8 weeks) were divided into four groups: Group I (Normal) without any treatment, Group II (Drug) was orally supplemented (GAE) once daily at the dose of 700 mg / kg. b.wt / day for 15 days, Group III (Control) only irradiated group, and GroupIV (IR+Drug) was first exposed to 5 Gy of gamma radiation then administered with GAE same as group II. Mice were sacrificed at day 1 and 15 post irradiation. Result: Radiation induced deficit in different blood constituents GSH, sugar, and protein levels in the serum could be significantly increased, whereas radiation induced elevation of LPO and cholesterol levels were markedly decreased in GAE post-treated animals compared to the control group. Conclusion: It showed that GAE provides protection against radiation-induced alterations in blood of mice.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
