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Licensed Unlicensed Requires Authentication Published by De Gruyter August 13, 2009

Effect on Inhibition of Proliferation and Antioxidant Enzyme Level of Lippia nodiflora in EAC Cell Line Treated Mice

  • Durairaj Ashokkumar , Upal Kanti Mazumder , Malaya Gupta and V. Thamil Selvan

Objective: The methanol extract of Lippia nodiflora (MELN) (Verbenaceae) was evaluated for antitumor activity against Ehrlich's ascites carcinoma (EAC) bearing Swiss albino mice.Methods: MELN was administered at 200 and 400mg/kg body weight daily for 9 days after 24 h of tumor inoculation. After 18 h fasting, mice were sacrificed. The present study deals with the effect of MELN on the growth of transplantable murine tumor, life span of EAC bearing hosts. Hematological profiles and biochemical parameters were estimated for hepato-renal function and metabolism. Further, Antioxidant enzyme activities were investigated.Results: MELN showed significant (p < 0.001) decrease in tumor volume, packed cell volume and viable cell count and elevated the life span of EAC tumor bearing mice. Hematological profiles reverted to more/less normal levels in extract treated mice. The extract marginally altered serum enzymes, total proteins and bilirubin compared with that of EAC bearing mice. MELN significantly (p < 0.001) decreased the levels of lipid peroxidation and increased the levels of GSH, CAT and SOD.Conclusion: The results of the present study suggest that MELN exhibited significant antitumor activity may be due to the increase of antioxidant activity in EAC bearing mice.

Published Online: 2009-8-13

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston

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