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Licensed Unlicensed Requires Authentication Published by De Gruyter October 1, 2009

Static Electric Field by High Voltage Alternating Current Ameliorates Collagen-Induced Arthritis in Mice via the Inhibition of IL-1? Expression

Yuji Naito, Wataru Aoi, Mamoru Inoue, Tomohisa Takagi, Satomi Akagiri, Katsura Mizushima, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Masaharu Karita, Tomoaki Hiwatashi, Mikihiko Hase and Toshikazu Yoshikawa

Background and aim: The therapy of placing a living body in a static electric field by high voltage alternating current (EF-HVAC) has been developed in the field of complementary and integrative medicine in Japan. The aim of this study was to investigate whether the exposure of EF-HVAC ameliorated collagen-induced arthritis (CIA) in mice.Methods: CIA was induced in female DBA/1 mice by the injection of anti-type II collagen antibody and lipopolysaccharide. The group of EF-HVAC treatment was exposed EF-HVAC with a high voltage value of 12.7 KV for 6 hours per day in the closed cage starting on the day of the injection with anti-type II collagen antibody and throughout the remaining study period.Results: Both clinical arthritis scores as well as histological findings of joint inflammation were significantly reduced in mice treated with EF-HVAC compared to untreated mice. Further, the treatment with EF-HVAC significantly inhibited the increased expression of interleukin -1? mRNA in paws at day 3 after induction of arthritis. In conclusion, the exposure to EF-HVAC protected from the synovial inflammation of CIA in mice.Conclusion: Based on these data, the beneficial effects of EF-HVAC on a murine rheumatoid arthritis model may be attributed to its anti-inflammatory properties.

Published Online: 2009-10-1

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