Cassia sophera is a medicinally important plant belonging to the family Caesalpiniaceae. It is being used in the ailments of oxidative stress. Cassia sophera was successively extracted with chloroform (CSE1), ethyl acetate (CSE2), methanol (CSE3) and water (CSE4). Extracts demonstrated the presence of anthraquinones and flavonoids. Amongst all of the extracts, CSE2 exhibited highest total phenolic content (250.54 mg/gm) as well as antiulcer potential using ethanol, pyloric ligation, hypothermic restrain stress and indomethacin-induced ulceration. Cassia sophera presented protection against ulceration, which may be because of both cytoprotective and antisecretary mechanisms. The phenolic content could be responsible for the gastro protective activity of CS.
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