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BY-NC-ND 4.0 license Open Access Published by De Gruyter October 18, 2016

Noise in Genetic Toggle Switch Models

  • M. Andrecut EMAIL logo and S. A. Kauffman

Summary

In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.

Published Online: 2016-10-18
Published in Print: 2006-6-1

© 2006 The Author(s). Published by Journal of Integrative Bioinformatics.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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