In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.
© 2006 The Author(s). Published by Journal of Integrative Bioinformatics.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.