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Open Access Published by De Gruyter Open Access January 16, 2013

Selective sorption of uric acid by novel molecularly imprinted polymers

  • Anastasia P. Leshchinskaya EMAIL logo , Irina V. Polyakova , Anna R. Groshikova , Oleg A. Pisarev and Evgeniy F. Panarin
From the journal Molecular Imprinting


The polymers based on ethylene glycol dimethacrylate (EGDMA) and dimethylaminoethyl methacrylate (DMAEMA) and molecularly imprinted with uric acid (UA), UA-MIPs, were successfully synthesized. The binding activity of UA-MIPs towards UA was studied in depth using batch methods. The optimized sorbent UA-MIP-7-16 was synthesized; this is an EGDMAcrosslinked system containing 16 mol% of UA as the template. The character of binding between UA and UA-MIP-7-16 was studied using xanthine as a reference substance, since its chemical structure is similar to that of UA. The studies of equilibrium sorption of UA and xanthine from model aqueous solutions by the imprinted sorbent demonstrate the predominance of specific UA sorption. The sorption kinetic data were analyzed using the Boyd model and shell and core. Selectivity of UAMIP- 7-16 was further demonstrated by biochemical analysis of serum containing UA and other components conducted before and after sorption. UA-MIP-7-16 showed high recognition selectivity and affinity towards the template molecule (UA).


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Received: 2012-4-20
Accepted: 2012-7-10
Published Online: 2013-01-16

©2012 Versita Sp. z o.o.

This content is open access.

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