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Open Access Published by De Gruyter Open Access February 27, 2013

Twenty years since ‘antibody mimics’ by molecular imprinting were first proposed: A critical perspective

Jenna L. Bowen , Panagiotis Manesiotis and Chris J. Allender EMAIL logo
From the journal Molecular Imprinting

Abstract

In February 1993, the group of Klaus Mosbach published their milestone study in Nature where, for the first time, non-covalent molecular imprints were employed in a competitive binding assay. In this seminal piece of work, and also for the first time, they refer to molecularly imprinted polymers as being ‘antibody mimics’ and hypothesised that these synthetic materials could one day provide ‘a useful, general alternative to antibodies’. This perspective article examines how far we have come in the 20 years since this publication in terms of realising this hypothesis and poses the question of whether we actually need molecularly imprinted polymers to be a general alternative to antibodies.

References

Wulff G. and Sarhan A., Use of polymers with enzymeanalogous structures for the resolution of racemates. Angew. Chem. Int. Ed. Engl., 1972, 11(4), 341. Search in Google Scholar

Vlatakis G., et al., Drug assay using antibody mimics made by molecular imprinting. Nature, 1993, 361(6413), 645-647. Search in Google Scholar

Alexander C., et al., Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003. J. Mol. Recognit., 2006, 19(2), 106-180. 10.1002/jmr.760Search in Google Scholar

MIP Database. (accessed: 05/02/2012); Available from: www.mipdatabase.com. Search in Google Scholar

Pichon V. and Chapuis-Hugon F., Role of molecularly imprinted polymers for selective determination of environmental pollutants - A review. Anal. Chim. Acta, 2008, 622(1-2), 48-61. 10.1016/j.aca.2008.05.057Search in Google Scholar

Manesiotis P., et al., Applications of SPE-MIP in the field of food analysis, in Comprehensive Sampling and Sample Preparation, J. Pawliszyn, Editor. 2012, Elsevier. 10.1016/B978-0-12-381373-2.00144-7Search in Google Scholar

Manesiotis P., Osmani Q., and McLoughlin P., An enantioselective chromatographic stationary phase for S-ibuprofen prepared by stoichiometric molecular imprinting. J. Mater. Chem., 2012, 22(22), 11201-11207. 10.1039/c2jm16659cSearch in Google Scholar

Ansell R.J., Molecularly imprinted polymers for the enantioseparation of chiral drugs. Adv. Drug Delivery Rev., 2005, 57(12), 1809-1835. 10.1016/j.addr.2005.07.014Search in Google Scholar

Zurutuza A., et al., Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Anal. Chim. Acta, 2005, 542(1), 14-19. 10.1016/j.aca.2004.12.019Search in Google Scholar

Kryscio D.R. and Peppas N.A., Critical review and perspective of macromolecularly imprinted polymers. Acta Biomaterialia, 2012, 8(2), 461-473. 10.1016/j.actbio.2011.11.005Search in Google Scholar

Sellergren B., ed. Molecularly Imprinted Polymers - Manmade mimics of antibodies and their applications in analytical chemistry. 2001, Elsevier. Search in Google Scholar

Haupt K. and Mosbach K., Plastic antibodies: developments and applications. Trends Biotechnol., 1998, 16(11), 468- 475. 10.1016/S0167-7799(98)01222-0Search in Google Scholar

Saper C.B., An open letter to our readers on the use of antibodies. J. Comp. Neurol., 2005, 493(4), 477-478. 10.1002/cne.20839Search in Google Scholar PubMed

Couchman J.R., Commercial antibodies: The good, bad, and really ugly. J. Histochem. Cytochem., 2009, 57(1), 7-8. 10.1369/jhc.2008.952820Search in Google Scholar PubMed PubMed Central

Coico R. and Sunshine G., Immunology: A Short Course. 6th ed. 2009: Wiley-Blackwell. Search in Google Scholar

Manesiotis P., et al., Water-compatible imprinted polymers for selective depletion of riboflavine from beverages. J. Mater. Chem., 2009, 19(34), 6185-6193. 10.1039/b906117gSearch in Google Scholar

Asanuma H., Hishiya T., and Komiyama M., Tailor-made receptors by molecular imprinting. Adv. Mater., 2000, 12(14), 1019-1030. 10.1002/1521-4095(200007)12:14<1019::AID-ADMA1019>3.0.CO;2-KSearch in Google Scholar

Janiak D.S. and Kofinas P., Molecular imprinting of peptides and proteins in aqueous media. Anal. Bioanal. Chem., 2007, 389(2), 399-404. 10.1007/s00216-007-1327-7Search in Google Scholar

Manesiotis P., et al., An artificial riboflavin receptor prepared by a template analogue imprinting strategy. Angew. Chem., Int. Ed. Engl., 2005, 44(25), 3902-3906. 10.1002/anie.200500342Search in Google Scholar

Nicholls I.A. and Andersson H.S., Thermodynamic principles underlying molecularly imprinted polymer formulation and ligand recognition, in Molecularly Imprinted Polymers - Man-made Mimics of Antibodies and their Applications in Analytical Chemistry, B. Sellergren, Editor. 2001, Elsevier. 10.1016/S0167-9244(01)80006-8Search in Google Scholar

Turner N.W., et al., From 3D to 2D: A review of the molecular imprinting of proteins. Biotechnol. Prog., 2006, 22(6), 1474- 1489. 10.1002/bp060122gSearch in Google Scholar

Bossi A., et al., Molecularly imprinted polymers for the recognition of proteins: The state of the art. Biosens. Bioelectron., 2007, 22(6), 1131-1137. 10.1016/j.bios.2006.06.023Search in Google Scholar

Hart B.R. and Shea K.J., Synthetic peptide receptors: Molecularly imprinted polymers for the recognition of peptides using peptide-metal interactions. J. Am. Chem. Soc., 2001, 123(9), 2072-2073. 10.1021/ja005661aSearch in Google Scholar

Kempe M., Glad M., and Mosbach K., An approach towards surface imprinting using the enzyme ribonuclease A. J. Mol. Recognit., 1995, 8(1-2), 35-9. 10.1002/jmr.300080106Search in Google Scholar

Mallik S., et al., Towards materials for the specific recognition and separation of proteins. New J. Chem., 1994, 25(30), 299-304. 10.1002/chin.199430304Search in Google Scholar

Titirici M.M., Hall A.J., and Sellergren B., Hierarchical imprinting using crude solid phase peptide synthesis products as templates. Chem. Mater., 2003, 15(4), 822-824. 10.1021/cm025770jSearch in Google Scholar

Titirici M.M. and Sellergren B., Peptide recognition via hierarchical imprinting. Anal. Bioanal. Chem., 2004, 378(8), 1913-1921. 10.1007/s00216-003-2445-5Search in Google Scholar

Rachkov A. and Minoura N., Recognition of oxytocin and oxytocin-related peptides in aqueous media using a molecularly imprinted polymer synthesized by the epitope approach. J. Chromatogr. A., 2000, 889(1-2), 111-118. 10.1016/S0021-9673(00)00568-9Search in Google Scholar

Rachkov A. and Minoura N., Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach. Biochim. Biophys. Acta, 2001, 1544(1-2), 255- 266. 10.1016/S0167-4838(00)00226-0Search in Google Scholar

Nishino H., Huang C.-S., and Shea K.J., Selective protein capture by epitope imprinting. Angew. Chem., Int. Ed. Engl., 2006, 45(15), 2392-2396. 10.1002/anie.200503760Search in Google Scholar PubMed

Hoshino Y., et al., Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: A plastic antibody. J. Am. Chem. Soc., 2010, 132(19), 6644- 6645. 10.1021/ja102148fSearch in Google Scholar PubMed PubMed Central

Hoshino Y., et al., Peptide imprinted polymer nanoparticles: A plastic antibody. J. Am. Chem. Soc., 2008, 130(46), 15242- 15243. 10.1021/ja8062875Search in Google Scholar PubMed

Hoshino Y., et al., Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. Small, 2009, 5(13), 1562-1568. 10.1002/smll.200900186Search in Google Scholar PubMed PubMed Central

Cutivet A., et al., Molecularly imprinted microgels as enzyme inhibitors. J. Am. Chem. Soc., 2009, 131(41), 14699-14702. 10.1021/ja901600eSearch in Google Scholar PubMed

Received: 2012-12-12
Accepted: 2013-02-15
Published Online: 2013-02-27

©2013 Versita Sp. z o.o.

This content is open access.

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