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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access June 1, 2006

Preparation of N-aryl-ketonitrone spin traps

  • Inas Hassan EMAIL logo , Robert Lauricella and Béatrice. Tuccio
From the journal Open Chemistry


The syntheses of seven N-aryl-C,C-dialkoxycarbonylnitrones 1–7, six of which were original, were achieved from the appropriate aryl-nitroso compounds. These ketonitrones were found to trap efficiently carbon-centred free radicals in aqueous media, yielding stable aminoxyl radicals whose EPR spectra lasted several days. The two penta-deuterated compounds 6 and 7 were also found to be efficient at trapping methoxyl radical. Their various spin adducts showed simple three line signals, very sensitive to the polarity of the environment. This study represents the very first use of linear ketonitrones as spin traps.

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Published Online: 2006-6-1
Published in Print: 2006-6-1

© 2006 Versita Warsaw

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