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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access December 1, 2007

Dopamine and iron mediated fragmentation of galactocerebroside and cardiolipin in micelles

  • Irina Yurkova EMAIL logo , Mikhail Kisel , Juergen Arnhold and Oleg Shadyro
From the journal Open Chemistry


Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and thin-layer chromatography (TLC) have been used to study dopamine and iron mediated free-radical transformation of lipids in their hydrophilic parts. It has been shown that the action of the dopamine/Fe2+ system on galactocerebroside or cardiolipin, which are the components of mixed micelles, results in formation of ceramide or phosphatidic acid and phosphatidylhydroxyacetone, respectively. These data, when combined with results obtained using the ascorbate/Fe2+/H2O2 oxidizing system with the same substrates, demonstrate that the formation of these products proceeds via an OH-radical induced fragmentation taking place in polar moiety of the starting lipids.

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Published Online: 2007-12-1
Published in Print: 2007-12-1

© 2007 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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