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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access August 11, 2008

Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water

Noora Kuuloja, Tuula Kylmälä, Youjun Xu and Robert Franzén
From the journal Open Chemistry

Abstract

Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively.

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Published Online: 2008-8-11
Published in Print: 2008-9-1

© 2008 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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