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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access August 11, 2008

Synthesis and structural peculiarities of gallium Complexes with novel paullone derivatives

Werner Ginzinger, Vladimir Arion, Gerald Giester, Markus Galanski and Bernhard Keppler
From the journal Open Chemistry

Abstract

9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine was reacted with 2-acetylpyridine to give a Schiff base as a potential tridentate ligand. The reaction of this ligand with gallium chloride afforded complexes of 1:1 and 2:1 stoichiometry. The results of X-ray diffraction studies of the ligand and both gallium complexes are reported and compared with the data for a related gallium complex with a Schiff base obtained from 9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine and 2-hydroxybenzaldehyde.

[1] D.W. Zaharevitz, R. Gussio, M. Leost, A.M. Senderowicz, T. Lahusen, C. Kunick, L. Meijer, E.A. Sausville, Cancer Res. 59, 2566 (1999). Search in Google Scholar

[2] E.B. Skibo, X. Huang, R. Martinez, R.H. Lemus, W.A. Craigo, J. Med. Chem. 55, 5543 (2002). http://dx.doi.org/10.1021/jm020285l10.1021/jm020285lSearch in Google Scholar

[3] C. Schultz, A. Link, M. Leost, D.W. Zaharevitz, R. Gussio, E.A. Sausville, L. Meijer, Kunick, J. Med. Chem. 42, 2909 (1999). http://dx.doi.org/10.1021/jm990057010.1021/jm9900570Search in Google Scholar

[4] J. Trapp, A. Jochum, R. Meier, L. Saunders, B. Marshall C. Kunick, E. Verdin, P. Goekjian, W. Sippl, M. Jung, J. Med. Chem. 49, 7307 (2006) http://dx.doi.org/10.1021/jm060118b10.1021/jm060118bSearch in Google Scholar

[5] W.F. Schmid, S. Zorbas-Seifried, R.O. John, V.B. Arion, M.A. Jakupec, A. Roller, M. Galanski, I. Chiorescu, H. Zorbas, B.K. Keppler, Inorg. Chem. 46, 3645 (2007). http://dx.doi.org/10.1021/ic070098j10.1021/ic070098jSearch in Google Scholar

[6] W.F. Schmid, R.O. John, G. Muehlgassner, P. Heffeter, M.A. Jakupec, M. Galanski, W. Berger, V.B. Arion, B.K. Keppler, J. Med. Chem. 50, 6343 (2007). http://dx.doi.org/10.1021/jm701042w10.1021/jm701042wSearch in Google Scholar

[7] A. Dobrov, V.B. Arion, N. Kandler, W. Ginzinger, M.A. Jakupec, A. Rufinska, N. Graf von Keyserlingk, M. Galanski, C. Kowol, B.K. Keppler, Inorg. Chem. 45, 1945 (2006). http://dx.doi.org/10.1021/ic051112010.1021/ic0511120Search in Google Scholar

[8] Z. Otwinowski, W. Minor, In: C.W. Carter Jr., R.M. Sweet, (Eds.), Methods in Enzymology Vol. 276: Macromolecular Crystallography Part A (Academic Press, London, 1997), 307 http://dx.doi.org/10.1016/S0076-6879(97)76066-X10.1016/S0076-6879(97)76066-XSearch in Google Scholar

[9] G.M. Sheldrick, SHELXS-97, Program for Crystal Structure Solution, University of Goettingen, Goettingen (1997) Search in Google Scholar

[10] Sheldrick G. M., SHELXL-97, Program for Crystal Structure Refinement, University of Goettingen, Goettingen (1997) Search in Google Scholar

[11] A.J.C. Wilson (Ed.), International Tables for X-ray Crystallography Vol. C (Kluwer Academic Publishers, Dordrecht, 1992), Tables 4.2.6.8 and 6.1.1.4 Search in Google Scholar

[12] A.L. Spek, J. Appl. Cryst. 36, 7 (2003). http://dx.doi.org/10.1107/S002188980202211210.1107/S0021889802022112Search in Google Scholar

[13] Bruker, XP (Version 5.1), Bruker AXS Inc., Madison, Wisconsin, USA (1998) Search in Google Scholar

[14] A.W. Addison, T.N. Rao, J. Reedijk, J. van Rijn, G.C. Verschoor, J. Chem. Soc. Dalton Trans. 7, 1349 (1984). http://dx.doi.org/10.1039/dt984000134910.1039/DT9840001349Search in Google Scholar

[15] K. Robinson, G.V. Gibbs, P.H. Ribbe, Science 172, 567 (1971). http://dx.doi.org/10.1126/science.172.3983.56710.1126/science.172.3983.567Search in Google Scholar PubMed

Published Online: 2008-8-11
Published in Print: 2008-9-1

© 2008 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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