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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access February 16, 2010

Simultaneous spectrophotometric determination of phenanthridine, phenanthridinone and phenanthridine N-oxide using multivariate calibration methods

Mohammad-Hossein Sorouraddin, Kaveh Amini, Abdolhossein Naseri and Mohammad-Reza Rashidi
From the journal Open Chemistry

Abstract

The multivariate calibration methods, partial least squares (PLS) and principle component regression (PCR) have been used to determine phenanthridine, phenanthridinone and phenanthridine N-oxide in spiked human plasma samples. Resolution of binary and ternary mixtures of analytes with minimum sample pre-treatment and without analyte separation has been successfully achieved analyzing the UV spectral data. The net analyte signal (NAS) concept was also used to calculate multivariate analytical figures of merit such as limit of detection, selectivity and sensitivity. The simultaneous determination of three analytes was possible by PLS and PCR processing of sample absorbance in the 210–355 nm region. Good recoveries were obtained for both synthetic mixtures and spiked human plasma samples.

[1] N. Tunc, F. Yilmaz, M. Ulgen, J.W. Gorrod, Eur. J. Drug Metab. Pharmacokinet. 22, 345 (1997) 10.1007/BF03190969Search in Google Scholar

[2] M.J. Ronne, Dairy Sci. 72, 1363 (1989) http://dx.doi.org/10.3168/jds.S0022-0302(89)79243-210.3168/jds.S0022-0302(89)79243-2Search in Google Scholar

[3] E.H. Elgemeie Galal, M.E.A. Adel, M.F. Nahed, Chem. Res. (S) 112 (1997) 10.1039/a606232fSearch in Google Scholar

[4] M.H. Sorouraddin, E. Fooladi, A. Naseri, M.R. Rashidi, J. Biophys. Biochem. Meth. 22, 6999 (2008) Search in Google Scholar

[5] K. Tokumura, H. Goto, H. Kashiwabara, C. Kaneko, M. Itoh, J. Am. Chem. Soc. 102, 5643 (1980) http://dx.doi.org/10.1021/ja00537a04010.1021/ja00537a040Search in Google Scholar

[6] P. Mamalis, V. Petrow, J. Chem. Soc. 703 (1950) 10.1039/jr9500000703Search in Google Scholar

[7] J.C. Craig, K.K. Purushothaman, J. Org. Chem. 35, 1721 (1970) http://dx.doi.org/10.1021/jo00830a12110.1021/jo00830a121Search in Google Scholar

[8] P. Devoogt, E.A.J. Bleeker, J. Chromatogr. B 724, 265 (1999) http://dx.doi.org/10.1016/S0378-4347(98)00592-110.1016/S0378-4347(98)00592-1Search in Google Scholar

[9] L. Lam, K. Sagkaguchi, Anal. Sci. 22, 325 (2006) http://dx.doi.org/10.2116/analsci.22.10510.2116/analsci.22.105Search in Google Scholar PubMed

[10] M. Shamsipur, R. Ghavami, H. Sharghi, B. Hemmateenejad, Ann. Chim. 95, 63 (2005) http://dx.doi.org/10.1002/adic.20059000810.1002/adic.200590008Search in Google Scholar PubMed

[11] H. Martens, T. Naes, Multivariate Calibration (Wiley, Chichester, 1989) Search in Google Scholar

[12] R. Ergon, Chemometr. Intell. Lab. Syst. 81, 68 (2006) http://dx.doi.org/10.1016/j.chemolab.2005.09.00810.1016/j.chemolab.2005.09.008Search in Google Scholar

[13] M. Daszykowski, S. Serneels, K. Kaczmarek, P.V. Espen, C. Croux, B. Walczak, Chemometr. Intell. Lab. Syst. 85, 269 (2007) http://dx.doi.org/10.1016/j.chemolab.2006.03.00610.1016/j.chemolab.2006.03.006Search in Google Scholar

[14] P. Druilhet, A. Mom, J. Multivar. Anal. 97, 1313 (2006) http://dx.doi.org/10.1016/j.jmva.2005.06.00910.1016/j.jmva.2005.06.009Search in Google Scholar

[15] B. Hemmateenejad, R. Ghavami, R. Miri, M. Shamsipur, Talanta 68, 1222 (2006) http://dx.doi.org/10.1016/j.talanta.2005.07.04510.1016/j.talanta.2005.07.045Search in Google Scholar

[16] W. Muth, J.C. Ellers, O.F. Folmer, J. Am. Chem. Soc. 79, 6500 (1957) http://dx.doi.org/10.1021/ja01581a03710.1021/ja01581a037Search in Google Scholar

[17] H.C. Goicoechea, A.C. Olivieri, Trends in Anal. Chem. 19, 599 (2000) http://dx.doi.org/10.1016/S0165-9936(00)00045-510.1016/S0165-9936(00)00045-5Search in Google Scholar

[18] J.C. Miller, J.N. Miller, Statistics for Analytical Chemistry, 2nd edition (Wiley, New York, 1988) Search in Google Scholar

[19] P.R. Griffiths, J.A. de Haseth, Fourier Transform Infrared Spectrometry, 2nd edition (Wiley, New York, 2007) 10.1002/047010631XSearch in Google Scholar

[20] R. Ergon, Chemom. Intell. Lab. Syst. 65, 293 (2003) http://dx.doi.org/10.1016/S0169-7439(02)00159-410.1016/S0169-7439(02)00159-4Search in Google Scholar

[21] P. Geladi, B.R. Kowalski, Anal. Chim. Acta 185, 1 (1986) http://dx.doi.org/10.1016/0003-2670(86)80028-910.1016/0003-2670(86)80028-9Search in Google Scholar

[22] A. Lorber, L. Wangen, B.R. Kowalski, J. Chemom. 1, 19 (1987) http://dx.doi.org/10.1002/cem.118001010510.1002/cem.1180010105Search in Google Scholar

[23] S. Wold, J. Trygg, A. Berglund, H. Antti, Chemom. Intell. Lab. Syst. 58, 131 (2001) http://dx.doi.org/10.1016/S0169-7439(01)00156-310.1016/S0169-7439(01)00156-3Search in Google Scholar

[24] H. Martens, Chemom. Intell. Lab. Syst. 58, 85 (2001) http://dx.doi.org/10.1016/S0169-7439(01)00153-810.1016/S0169-7439(01)00153-8Search in Google Scholar

[25] J.M.L. Gallego, J.P. Arroyo, Anal. Chim. Acta 460, 85 (2002) http://dx.doi.org/10.1016/S0003-2670(02)00138-110.1016/S0003-2670(02)00138-1Search in Google Scholar

[26] J. Ghasemi, A. Niazi, Michrochem. J. 68, 1 (2001) http://dx.doi.org/10.1016/S0026-265X(00)00159-410.1016/S0026-265X(00)00159-4Search in Google Scholar

[27] A. Donachie, A.D. Walmsley, S.J. Haswell, Anal. Chim. Acta 378, 235 (1999) http://dx.doi.org/10.1016/S0003-2670(98)00609-610.1016/S0003-2670(98)00609-6Search in Google Scholar

[28] P.D. Wentzell, L.V. Montono, Chemom. Intell. Lab. Syst. 65, 257 (2003) http://dx.doi.org/10.1016/S0169-7439(02)00138-710.1016/S0169-7439(02)00138-7Search in Google Scholar

[29] P.C. Damiani, A.C. Moschetti, A.J. Rovetto, F. Benavente, A.C. Olivieri, Anal. Chim. Acta 543, 192 (2005) http://dx.doi.org/10.1016/j.aca.2005.04.06510.1016/j.aca.2005.04.065Search in Google Scholar

[30] M.M. Galera et al., Talanta 59, 1107 (2003) http://dx.doi.org/10.1016/S0039-9140(03)00021-310.1016/S0039-9140(03)00021-3Search in Google Scholar

Published Online: 2010-2-16
Published in Print: 2010-2-1

© 2010 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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