Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access December 16, 2010

Silver nanoparticles: synthesis through chemical methods in solution and biomedical applications

  • Jorge García-Barrasa EMAIL logo , José López-de-Luzuriaga and Miguel Monge
From the journal Open Chemistry


Chemical methods provide an easy way to synthesize silver nanoparticles (Ag NPs) in solution. These metal nanoparticles have a great potential for biomedical applications as an antibacterial, antifungal, and antiviral agent or in wound healing. The adjustment of the parameters involved in these reactions permits a precise control over the size, shape, monodispersity, and the surfaces of the nanoparticles. These nanoparticles are being used in the design of new hybrid organic-inorganic or inorganic nanomaterials for biomedical applications.

[1] C.N.R. Rao, A. Müller, A.K. Cheetham (Eds), The Chemistry of Nanomaterials. Synthesis, Properties and Applications (Wiley-VCH Verlag, Weinheim, 2004) Vols. 1 and 2 Search in Google Scholar

[2] C.N.R. Rao, A. Müller, A.K. Cheetham (Eds), Nanomaterials Chemistry. Recent Developments and New Directions (Wiley-VCH Verlag, Weinheim, 2007) Search in Google Scholar

[3] C. Burda, X. Chen, R. Narayanan, M.A. El-Sayed, Chem. Rev. 105, 1025 (2005) in Google Scholar

[4] B.L. Cushing, V.L. Koleschineko, C.J. O’Connor, Chem. Rev. 104, 3893 (2004) in Google Scholar

[5] H.J. Klasen, Burns 26, 117 (2000) in Google Scholar

[6] H.J. Klasen, Burns 26, 131 (2000) in Google Scholar

[7] D.J. Barber, I.C. Freestone, Archaeometry 32, 33 (1990) in Google Scholar

[8] J. Pérez-Arantegui, A. Larrea, Trends Anal. Chem. 22, 327 (2003) in Google Scholar

[9] A. Caiger-Smith, Lustre Pottery: Technique, Tradition and Innovation in Islam and the Western World (Faber & Faber, London, 1985) Search in Google Scholar

[10] L.M. Liz-Marzán, Materials Today Feb, 26, (2004) 10.1016/S1369-7021(04)00080-XSearch in Google Scholar

[11] L.S. Nair, C. T. Laurencin, J. Biomed. Nanotechnol. 3, 301 (2007) in Google Scholar

[12] D.D. Evanoff, Jr., G. Chumanov, ChemPhysChem. 6, 1221 (2005) in Google Scholar PubMed

[13] P.C. Lee, D.J. Meisel, Phys. Chem. 86, 3391 (1982) in Google Scholar

[14] J.A. Creighton, C.G. Blatchford, M.G. Albrecht, J. Chem. Soc. Farad. Trans. II 75, 790 (1979) in Google Scholar

[15] K.P. Velikov, G.E. Zegers, A. van Blaaderen, Langmuir 19, 1384 (2003) in Google Scholar

[16] L.K. Kurihara, G.M. Chow, P.E. Schoen, Nanostruct. Mater. 5, 607 (1995) in Google Scholar

[17] J.A. Jacob, S. Kapoor, N. Biswas, T. Mukherjee, Colloids Surf., A Physicochem. Eng. Aspects 301, 329 (2007) in Google Scholar

[18] P. Raveendran, J. Fu, S.L. Wallen, J. Am. Chem. Soc. 125, 13940, (2003) in Google Scholar PubMed

[19] Y.D. Yin, Z.Y. Li, Z.Y. Zhong, B. Gates, Y.N. Xia, J. Mater. Chem. 12, 522 (2002) in Google Scholar

[20] I. Pastoriza-Santos, L.M. Liz-Marzán, Pure Appl. Chem. 72, 83, (2000) in Google Scholar

[21] I. Pastoriza-Santos, L.M. Liz-Marzán, Langmuir 18, 2888 (2002) in Google Scholar

[22] I. Pastoriza-Santos, L.M. Liz-Marzán, Nano Lett. 2, 903 (2002) in Google Scholar

[23] I. Pastoriza-Santos, D.S. Koktysh, A. A. Mamedov, M. Giersig, N. A. Kotov, L. M. Liz-Marzán, Langmuir 16, 2731 (2000) in Google Scholar

[24] I. Pastoriza-Santos, L.M. Liz-Marzán, J. Mat. Chem. 18, 1724 (2008) in Google Scholar

[25] M. Brust, C.J. Kiely, Colloids Surf. A Phys. Eng. Aspects 202, 175 (2002). in Google Scholar

[26] M.M. Oliveira, D. Ugarte, D. Zanchet, A.J.G. Zarbin, J. Colloid Interface Sci. 292, 429 (2005) in Google Scholar PubMed

[27] C.A. Bauer, F. Stellacci, J. W. Perry, Top. Catal. 47, 32 (2008) in Google Scholar

[28] M. Yamamoto, M. Nakamoto, J. Mat. Chem. 13, 2064 (2003) in Google Scholar

[29] Y. Kashiwagi, M. Yamamoto, M. Nakamoto, J. Colloid Interface Sci. 300, 169 (2006) in Google Scholar PubMed

[30] M. Green, N. Allsop, G. Wakefield, P.J. Dobson, J.L. Hutchison, J. Mat. Chem. 12, 2671 (2002) in Google Scholar

[31] H. Hiramatsu, F.E. Osterloh, Chem. Mater. 16, 2509 (2004) in Google Scholar

[32] S. Nath, S. Praharaj, S. Panigrahi, S. Kundu, S.K. Ghosh, S. Basu, T. Pal, Colloids Surf. A Phys. Eng. Aspects 274, 145 (2006) in Google Scholar

[33] S.D. Bunge, T.J. Boyle, T.J. Headley, Nano Lett. 3, 901, (2003) in Google Scholar

[34] N.R. Jana, L. Gearheart, C.J. Murphy, Chem. Commun. 617 (2001) 10.1039/b100521iSearch in Google Scholar

[35] C.J. Murphy, N.R. Jana, Adv. Mat. 14, 80 (2002)<80::AID-ADMA80>3.0.CO;2-#Search in Google Scholar

[36] S. Chen, D.L. Carroll Nano Lett 2, 1003 (2002) in Google Scholar

[37] J.P. Cason, K. Khanbaswadkar, C.B. Roberts, Ind. Eng. Chem. Res. 39, 4749 (2000) in Google Scholar

[38] M.P. Pileni, Pure Appl. Chem. 72, 53 (2000) in Google Scholar

[39] M. Maillard, S. Giorgio, M.P. Pileni, J. Phys. Chem. B 107, 2466 (2003) in Google Scholar

[40] W. Zhang, X. Qiao, J. Chen, H. Wang, J. Colloid Interface Sci. 302, 370 (2006) in Google Scholar PubMed

[41] Y. Sun, Y. Xia, Science 298, 2176 (2002) in Google Scholar PubMed

[42] H.H. Huang, X.P. Ni, G.L. Loy, C.H. Chew, K.L. Tan, F.C. Loh, J.F. Deng, G.Q. Xu, Langmuir 12, 909 (1996) in Google Scholar

[43] Y. Tan, X. Dai, Y. Li, D. Zhu, J. Mater. Chem. 13, 1069 (2003) in Google Scholar

[44] R. He, X. Qian, J. Yin, Z. Zhu, J. Mater. Chem. 12, 3783 (2002) in Google Scholar

[45] Y. Sun, Y. Xia, Adv. Mat. 14, 833 (2002)<833::AID-ADMA833>3.0.CO;2-K10.1002/1521-4095(20020605)14:11<833::AID-ADMA833>3.0.CO;2-KSearch in Google Scholar

[46] B. Wiley, Y. Sun, B. Mayers, Y. Xia, Chem. Eur. J. 11, 454 (2005) in Google Scholar

[47] Z.Q. Zhang, R.C. Patel, R. Kothari, C.P. Johnson, S.E. Friberg, P.A. Aikens, J. Phys. Chem. B 104, 1176 (2000) in Google Scholar

[48] Q. Yang, F. Wang, K.B. Tang, C.R. Wang, Z.W. Chen, Y.T. Qian, Mater. Chem. Phys. 78, 495 (2002) in Google Scholar

[49] Z.P. Zhang, M.Y. Han, J. Mater. Chem. 13, 641 (2003) in Google Scholar

[50] M. Cheng, L. Wang, J. Han, J. Zhang, Z. Lin, D. Qian, J. Chem. Phys. B 110, 11224 (2006) in Google Scholar

[51] K. Mallick, M.J. Witcomb, M.S. Scurrell, Mater. Sci. Eng., C 26, 87 (2006) in Google Scholar

[52] X. Sun, S. Dong, E. Wang, Macromolecules 37, 7105 (2004) in Google Scholar

[53] W. Lesniak, A.U. Bielinska, K. Sun, K.W. Janczak, X. Shi, J.R. Baker, Jr., L.P. Balogh, Nano Lett. 5, 2123 (2005) in Google Scholar

[54] J. Zheng, R.M. Dickson, J. Am. Chem. Soc. 123, 13982 (2002) in Google Scholar

[55] H. Huang, X. Yang, Carbohydr Res 339, 2627 (2004) in Google Scholar

[56] Q. Wu, H. Cao, Q. Luan, J. Zhang, Z. Wang, J.H. Warner, A.A.R. Watt, Inorg. Chem. 47, 5882 (2008) in Google Scholar

[57] A. Mantion, A.G. Guex, A. Foelske, L. Mirolo, K.M. Fromm, M. Painsid, A. Taubert, Soft Matter. 4, 606 (2008) in Google Scholar

[58] D. Yu, V.W.-W. Yam, J. Am. Chem. Soc. 126, 13200 (2004) in Google Scholar

[59] D. Yu, V.W.-W. Yam, J. Chem. Phys. B 109, 5497 (2005) in Google Scholar

[60] R. Jin, Y. Cao, C.A. Mirkin, K.C. Kelly, G.C. Schatz, J.G. Zheng, Science 294, 1901 (2001) in Google Scholar

[61] R. Jin, Y.C. Cao, E. Hao, G.S. Metraux, G.C. Schartz, C.A. Mirkin, Nature 425, 487 (2003) in Google Scholar

[62] A. Troupis, A. Hiskia, E. Papaconstantinou, Angew Chem. Int. Ed. 41, 1911 (2002)<1911::AID-ANIE1911>3.0.CO;2-010.1002/1521-3773(20020603)41:11<1911::AID-ANIE1911>3.0.CO;2-0Search in Google Scholar

[63] E.J. Fernández, J. García-Barrasa, A. Laguna, J.M. López-de-Luzuriaga, M. Monge, C. Torres, Nanotechnology 19, 185602 (6pp) (2008) in Google Scholar

[64] K. Philippot, B. Chaudret, C. R. Chimie 6, 1019 (2003) in Google Scholar

[65] B. Chaudret, C. R. Physique 6, 117 (2005) in Google Scholar

[66] M. Monge, M. L. Kahn, A. Maisonnat, B. Chaudret, Angew. Chem., Int. Ed. 42, 5321 (2003) in Google Scholar PubMed

[67] H. Schmidbaur, A. Grohmann, M.E. Olmos, A. Schier, In: S. Patai, Z. Rappoport (Eds), PATAI’s Chemistry of Functional Groups Organic Derivatives of Gold and Silver (John Wiley & Sons, Chichester 1999) Search in Google Scholar

[68] J.R. Morones, J.L. Elechiguerra, A. Camacho, K. Holt, J.B. Kouri, J.T. Ramírez, M.J. Yacaman, Nanotechnology 16, 2346 (2005) in Google Scholar PubMed

[69] J.L. Elechiguerra, J.L. Burt, J.R. Morones, A. Camacho-Bragado, X. Gao, H.H. Lara, M.J. Yacaman, J. Nanobiotechnology 3, 6 (2005) in Google Scholar PubMed PubMed Central

[70] C.N. Lok, C.M. Ho, R. Chen, Q.Y. He, W.Y. Yu, H. Sun, P.K.H. Tam, J.F. Chiu, C.M. Che, J. Proteome Res. 5, 916 (2006) in Google Scholar PubMed

[71] C.N. Lok, C.M. Ho, R. Chen, Q.Y. He, W.Y. Yu, H. Sun, P.K.H. Tam, J.F. Chiu, C.M. Che, J. Biol. Inorg. Chem. 12, 527 (2007) in Google Scholar PubMed

[72] N.V. Ayala-Núñez, H.H. Lara Villegas, L del C. Ixtepan Turrent, C. Rodríguez Padilla, Nanobiotechnol. 5, 1551 (2009) in Google Scholar

[73] S. Pal, Y.K. Tak, J.M. Song, Appl. Environ. Microb. 73, 1712 (2007) in Google Scholar PubMed PubMed Central

[74] N. Nino-Martinez, G.A. Martinez-Castanon, A. Aragon-Pina, F. Martinez-Gutierrez, J.R. Martinez-Mendoza, F. Ruiz, Nanotechnology 19, 065711 (2008) in Google Scholar PubMed

[75] D. Guin, S.V. Manorama, J.N.L. Latha, S. Singh, J. Phys. Chem. C 111, 13393 (2007) in Google Scholar

[76] B.S. Necula, L.E. Fratila-Apachitei, S.A.J. Zaat, I. Apachitei, J. Duszczyk, Acta Biomater. 5, 3573 (2009) in Google Scholar PubMed

[77] J. Mungkalasiri, L. Bedel, F. Emieux, J. Doré, F.N.R. Renaud, C. Sarantopoulos, F. Maury Chem. Vapor Depos. 16, 35 (2010) in Google Scholar

[78] S.K. Arumugam, TP. Sastry, SB. Sreedhar, A.S. Mandal, J. Biomed. Mater. Res. 80A, 391 (2007) in Google Scholar PubMed

[79] F.A. Sheikh, N.A.M. Barakat, M.A. Kanjwal, R. Nirmala, J.H. Lee, H. Kim, H.Y. Kim, J. Mater. Sci.: Mater. Med. 21, 2551 (2010) in Google Scholar PubMed

[80] M. Miranda, A. Fernández, M. Díaz, L. Esteban-Tejeda, S. López-Esteban, F. Malpartida, R. Torrecillas, J.S. Moya, Int. J. Mater. Res. 122 (2010) 10.3139/146.110256Search in Google Scholar

[81] J. Shen, M. Shi, N. Li, B. Yan, H. Ma, Y. Hu, M. Ye, Nano Res. 3, 339 (2010) in Google Scholar

[82] V.K. Rangari, G.M. Mohammad, S. Jeelani, A. Hundley, K. Vig, S.R. Singh, S. Pillai, Nanotechnology 21, 095102 (2010) in Google Scholar PubMed

[83] O. Akhavan, E. Ghaderi, Curr. Appl. Physics 9, 1381 (2009) in Google Scholar

[84] L. Jiang, W. Wang, D. Wu, J. Zhan, Q. Wang, Z. Wu, R. Jin, Mater. Chem. Phys. 104, 230 (2007) in Google Scholar

[85] W. Lu, G. Liu, S. Gao, S. Xing, J. Wang, Nanotechnology 19, 445711 (2008) in Google Scholar PubMed

[86] H. Koga, T. Kitaoka, H. Wariishi, J. Mat. Chem. 19, 2135 (2009) in Google Scholar

[87] P. Gong, H. Li, X. He, K. Wang, J. Hu, W. Tan, S. Zhang, X. Yang, Nanotechnology 18, 285604 (2007) in Google Scholar

[88] B. Chudasama, A.K. Vala, N. Andhariya, R.V. Upadhyay, R.V. Mehta, Nano Res. 2, 955 (2009) in Google Scholar

[89] H. Miyoshi, H. Ohno, K. Sakai, N. Okamura, H. Kourai, J. Coll. Interface Sci. 345, 433 (2010) in Google Scholar PubMed

[90] O. Ozay, A. Akcali, M.T. Otkun, C. Silan, N. Aktas, N. Sahiner, Colloids Surf. B 79, 460 (2010) in Google Scholar PubMed

[91] Y.M. Mohan, K. Vimala, V. Thomas, K. Varaprasad, B. Sreedhar, S.K. Bajpai, K.M. Raju, J. Coll. Interface Sci. 342, 73 (2010) in Google Scholar PubMed

[92] P. Jain, T. Pradeep, Biotechnol. Bioeng. 90, 59, (2005) in Google Scholar PubMed

[93] R. Bryaskova, D. Pencheva, M. Kyulavska, D. Bozukova, A. Debuigne, C. Detrembleur, J. Coll. Interface Sci. 344, 424 (2010) in Google Scholar PubMed

[94] K. Vimala, Y.M. Mohan, K.S. Sivudu, K. Varaprasad, S. Ravindra, N.N. Reddy, Y. Padma, B. Sreedhar, K.M. Raju, Colloids Surf. B 76, 248 (2010) in Google Scholar PubMed

[95] L. Balogh, D. Swanson, D. Tomalia, G. Hagnauer, A. McManus, Nano Lett. 1, 18 (2001) in Google Scholar

[96] Y. Zhang, H. Peng, W. Huang, Y. Zhou, D. Yan, J. Coll. Interface Sci. 325, 371 (2008) in Google Scholar PubMed

[97] S. Jaiswal, B. Duffy, A.K. Jaiswal, N. Stobie, P. McHale, Int. J. Antimicrob. Agents 36, 280 (2010) in Google Scholar PubMed

[98] M. Veerapandian, S.K. Lim, H.M. Nam, G. Kuppannan, K.S. Yun, Anal. Bioanal. Chem. 398, 867 (2010) in Google Scholar PubMed

[99] R.W.-Y. Sun, R. Chen, N.P.-Y. Chung, C.-M. Ho, C.-L.-S. Lin, C.-M. Che, Chem. Commun. 5059 (2005) Search in Google Scholar

[100] J.S. Kim, E. Ku, K.N. Yu, J. Kim, S.J. Park, H.J. Lee, S.H. Kim, Y.K. Park, Y.H. Park, C. Hwang, Y. Kim, Y. Lee, D.H. Jeong, M. Cho, Nanomedicine: Nanotechnology, Biology and Medicine 3, 95 (2007) in Google Scholar PubMed

[101] J. Tian, K.K.Y. Wong, C.M. Ho, C.N. Lok, W.Y. Yu, C.M. Che, J.F. Chiu, P.K.H. Tam, ChemMedChem. 2, 129, (2007) in Google Scholar PubMed

[102] D. Cheng, J. Yang, Y. Zhao, Chin. Med. Equip. J. 4, 26 (2004) Search in Google Scholar

[103] P. Muangman, C. Chuntrasakul, S. Silthram, S. Suvanchote, R. Benjathanung, S. Kittidacha, S. Rueksomtawin, J. Med. Assoc. Thai. 89, 953 (2006) Search in Google Scholar

[104] M.S. Cohen, J.M. Stern, A.J. Vanni, R.S. Kelley, E. Baumgart, D. Field, J.A. Libertino, I.C. Summerhayes, Surg. Infect. 8, 397 (2007) in Google Scholar PubMed

[105] A.B. Lansdown, Curr. Probl. Dermatol. 33, 17 (2006) in Google Scholar PubMed

[106] Z. Zhang, M. Yang, M. Huang, Y. Hu, J. Xie, Chin. J. Health Lab.Technol. 17, 1403 (2007) Search in Google Scholar

[107] D. Roe, B. Karandikar, N. Bonn-Savage, B. Gibbins, J.P. Roullet, J. Antimicrob. Chemother. 61, 869 (2008) in Google Scholar PubMed

[108] W. Chen, Y. Liu, H.S. Courtney, M. Bettenga, C.M. Agrawal, J.D. Bumdgardner, J.L. Ong, Biomaterials 27, 5512 (2006) in Google Scholar PubMed

[109] N.G. Khlebtsov, L.A. Dykman, J. Quant Spectr. Radiat. Transfer 1, 111 (2010) 10.1016/j.jqsrt.2009.08.006Search in Google Scholar

[110] M. Rai, A. Yadav, A. Gade, Biotecnol. Adv. 27, 76 (2009) in Google Scholar PubMed

[111] R. Vaidyanathan, K. Kalishwaralal, S. Gopalram, S. Gurunathan, Biotecnol. Adv. 27, 924 (2010) in Google Scholar PubMed

Published Online: 2010-12-16
Published in Print: 2011-2-1

© 2011 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 10.12.2023 from
Scroll to top button