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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access December 16, 2010

Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products

  • Judyta Cielecka-Piontek EMAIL logo , Aran Lunzer and Anna Jelińska
From the journal Open Chemistry


A first-derivative UV spectrophotometric method, with or without the subtraction technique, was developed for the determination of biapenem in pharmaceutical dosage form in the presence of its degradation products. The method was based on the measurement of first-derivative amplitudes at zero crossing point (λ = 312 nm) and the peak-to-zero technique and validated with regard to linearity, limits of detection and quantitation, selectivity and precision. The observed rate constants for the degradation of biapenem were comparable to those obtained in the stability-indicating HPLC method.

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Published Online: 2010-12-16
Published in Print: 2011-2-1

© 2011 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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