Novel heavy metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H2O)2 (1) (synthesized via a static self-assembly process) and Sn(phen)(NO3)(OH)(H2O) (2), Sn(5-NH2-phen)(OH)(Cl)(H2O) (3), Pb(5-NH2-phen)(NO3)2(H2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10−2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10−2 mg. The computed EC50 values of 1–4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10−3 to 6.31×10−6 M. Towards Lep-3 substances 2–4 showed IC50 7.52×10−4 − 0.44 M. Substance 1 possess EC50=1.26×10−7 M to the non-tumour cells.
 S.V. Larionov, R.F. Klevtsova, E.A. Sankova, L.A. Glinskaya, T.E. Kokina, Russ. J. Inorg. Chem. 53, 1417 (2008) http://dx.doi.org/10.1134/S003602360809012X10.1134/S003602360809012XSearch in Google Scholar
 M.S. Atanassova, G.D. Dimitrov, J. Univ. Chem. Technol. Metallurgy, Sofia, 37, 85 (2002) Search in Google Scholar
 G.D. Dimitrov, N. Kaloyanov, P. Petrov, D. Wesselinova, Compt. Rend. l’Acad. bulg. Sci. 61, 595 (2008) Search in Google Scholar
 D. Wesselinova, M. Neykov, N. Kaloyanov, R. Toshkova, G.D. Dimitrov, Eur. J. Med. Chem. 44, 2720 (2009) http://dx.doi.org/10.1016/j.ejmech.2009.01.03610.1016/j.ejmech.2009.01.036Search in Google Scholar PubMed
 N. Kaloyanov, R. Alexandrova, D.W. Wesselinova, H. Mayer-Figge, W.S. Sheldrick, G.D. Dimitrov, Eur. J. Med. Chem. 46, 1992 (2011) http://dx.doi.org/10.1016/j.ejmech.2011.02.01810.1016/j.ejmech.2011.02.018Search in Google Scholar PubMed
 E.J. Gao, Q.T. Liu, Acta Chim. Sinica 60, 674 (2002) Search in Google Scholar
 R.K. Narla, Y. Dong, O.J. D’Cruz, C. Navara, F.M. Uckun, Clin. Cancer Res. 6, 1546 (2000) Search in Google Scholar
 CellTiter 96 Non-Radioactive Cell proliferation assay, Technical Bulletin #TB112 (Promega Corporation, USA, December 1999) Search in Google Scholar
© 2012 Versita Warsaw
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.