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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access September 21, 2012

Enantioselective inhibition of immobilized acetylcholinesterase in biosensor determination of pesticides

Marzena Kaniewska, Justyna Jońca, Iwona Połeć, Tomasz Sikora, Jean-Louis Marty and Marek Trojanowicz
From the journal Open Chemistry


Chiral effects for the inhibition of acetylcholinesterase by organophosphorus pesticides were investigated for insecticide malathion and malaoxon, which is a metabolic product of malathion in living organisms. Studies were carried out using a bienzymatic biosensor with immobilized acetylcholinesterase, choline oxidase, and with Prussian Blue used as a mediator. In both cases the R enantiomers accelerate acetylocholinesterase inhibition. The chiral effect in inhibition was much more pronounced in fast flow measurements than in batch measurements.

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Published Online: 2012-9-21
Published in Print: 2012-12-1

© 2012 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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