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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access November 29, 2012

Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system

Nataša Pejić EMAIL logo , Nataša Sarap , Jelena Maksimović , Slobodan Anić and Ljiljana Kolar-Anić
From the journal Open Chemistry

Abstract

A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0°C, [H2SO4]0 = 7.60×10−2 mol L−1, [KIO3]0 = 5.90×10−2 mol L−1, [H2O2]0 = 1.50×10−1 mol L−1 and j 0 = 2.95×10−2 min−1), the linear relationship between maximal potential shift ΔE m , and PX concentration was obtained in the concentration range 11.2–480.5 µg mL−1 with a detection limit of 9.9 µg mL−1. The method had a rather good sample throughput of 25 samples h−1 with a precision RSD = 4.7% as well as recoveries RCV ≤ 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.

[1] Y. H. Chang, S.H. Dromgoole, In: H.E. Paulus, D.E. Furst, S.H. Dromgoole (Eds.), Drugs for Rheumatic Disease (Churchill Livingstone, New York, 1987) 389 Search in Google Scholar

[2] M. Starek, J. Krzek, Talanta 77, 925 (2009) http://dx.doi.org/10.1016/j.talanta.2008.09.02210.1016/j.talanta.2008.09.022Search in Google Scholar

[3] R. Jimenez-Prieto, M. Silva, D. Perez-Bendito, Anal. Chem. 67, 729 (1995) http://dx.doi.org/10.1021/ac00100a00710.1021/ac00100a007Search in Google Scholar

[4] W. C. Bray, J. Am. Chem. Soc. 43, 1262 (1921) http://dx.doi.org/10.1021/ja01439a00710.1021/ja01439a007Search in Google Scholar

[5] W. C. Bray, H.A. Liebhafsky, J. Am. Chem. Soc. 53, 38 (1931) http://dx.doi.org/10.1021/ja01352a00610.1021/ja01352a006Search in Google Scholar

[6] P. Gray, S. Scott, Chemical oscillations and instabilities: nonlinear chemical kinetics (Oxford University Press, Oxford, 1990) Search in Google Scholar

[7] R. Jimenez-Prieto, M. Silva, D. Perez-Bendito, Analyst 23, 1R (1998) http://dx.doi.org/10.1039/a703354k10.1039/a703354kSearch in Google Scholar

[8] N. Pejić, Hem. Ind. 63, 455 (2009) (In Serbian) Search in Google Scholar

[9] J. Z. Gao, J. Biol. Sci. 8, 512 (2005) 10.1016/j.jvcir.2004.12.001Search in Google Scholar

[10] J. Gao, Y. Liu, J. Ren, X. X. Niu, Y. Zhang, W. Yang, Cent. Eur. J. Chem. 7, 298 (2009) http://dx.doi.org/10.2478/s11532-009-0060-910.2478/s11532-009-0060-9Search in Google Scholar

[11] J. Maksimović, Lj. Kolar-Anić Lj., S. Anić, D. Ribič, N. Pejić, J. Braz. Chem. Soc. 22, 38 (2011) Search in Google Scholar

[12] G. Hu, L. Chen, J. Zhang, P. Chen, W. Wang, J. Song, L. Qui, J. Song, L. Hu, Cent. Eur. J. Chem. 7, 291 (2009) http://dx.doi.org/10.2478/s11532-009-0042-y10.2478/s11532-009-0042-ySearch in Google Scholar

[13] J. Gao, X. Chen, J. Ren, W. Yang, J. Braz. Chem. Soc. 22, 648 (2011) Search in Google Scholar

[14] V. Vukojević, N. Pejić, D. Stanisavljev, S. Anić, Lj. Kolar-Anić, Analyst 124, 147 (1999) http://dx.doi.org/10.1039/a807608a10.1039/a807608aSearch in Google Scholar

[15] P. E. Strizhak, O.Z. Didenko, T.S. Ivashchenko, Anal. Chim. Acta 428, 15 (2001) http://dx.doi.org/10.1016/S0003-2670(00)01253-810.1016/S0003-2670(00)01253-8Search in Google Scholar

[16] J. Gao, Y. Zhang, J. Ren, M. Li, W. Yang, Cen. Eur. J. Chem. 8, 602 (2010) http://dx.doi.org/10.2478/s11532-010-0025-z10.2478/s11532-010-0025-zSearch in Google Scholar

[17] P. Strizhak, V. Khavrus, Talanta 51, 935 (2000) http://dx.doi.org/10.1016/S0039-9140(99)00363-X10.1016/S0039-9140(99)00363-XSearch in Google Scholar

[18] V. Vukojević, S. Anić, Lj. Kolar-Anić, J. Phys. Chem. 104, 10731 (2000) http://dx.doi.org/10.1021/jp001165x10.1021/jp001165xSearch in Google Scholar

[19] M. Milošević, N. Pejić, & Z. Čupić, S. Anić, Lj. Kolar-Anić, Materials Sci. Forum 494, 369 (2005) http://dx.doi.org/10.4028/www.scientific.net/MSF.494.36910.4028/www.scientific.net/MSF.494.369Search in Google Scholar

[20] N. Pejić, J. Maksimović, D. Ribič, Lj. Kolar-Anić, Russ. J. Phys. Chem. A 83, 1666 (2009) 10.1134/S0036024409090131Search in Google Scholar

[21] N. Pejić, M. Vujković, J. Maksimović, A. Ivanović, S. Anić, & Z. Čupić, Lj. Kolar-Anić, Russ. J. Phys. Chem. A 85, 66 (2011) 10.1134/S0036024411130231Search in Google Scholar

[22] N. Pejić, S. Blagojević, J. Vukelić, Lj. Kolar-Anić, S. Anić, Bull. Chem. Soc. Jpn. 50, 1942 (2007) Search in Google Scholar

[23] Y. A. Yaraliev, Uspekhi Khimii 51, 990 (1982) (In Russian) 10.1070/RC1982v051n06ABEH002866Search in Google Scholar

[24] International Conference on Harmonization (ICH), Harmonized tripartite guideline validation of analytical procedures: text and methodology, Q2(R1), 2005 J. International Conference on Harmonization (ICH), Harmonized tripartite guideline validation of analytical procedures: text and methodology, Q2(R1), 2005 Search in Google Scholar

[25] J.C. Miller, J.N. Miller, Statistics for Analytical Chemistry, 2nd edition (Ellis Horwood Ltd, New York, 1988) Search in Google Scholar

[26] M. Silva, M. Garcia, J. Lima, E. Barrado, Electroanalysis 19, 1362 (2007) http://dx.doi.org/10.1002/elan.20070385610.1002/elan.200703856Search in Google Scholar

[27] S. Khalil, N. Borham, M. El-Ries, Anal. Chim. Acta 414, 215 (2000) http://dx.doi.org/10.1016/S0003-2670(00)00760-110.1016/S0003-2670(00)00760-1Search in Google Scholar

[28] K. Asadpour-Zeynali, M. Majidi, M. Zarifi, Cent. Eur. J. Chem. 8, 155 (2010) http://dx.doi.org/10.2478/s11532-009-0122-z10.2478/s11532-009-0122-zSearch in Google Scholar

[29] M. A. El-Ries, G. Mohamed, S. Khalil, M. El-Shall, Chem. Pharm. Bull. 51, 6 (2003) http://dx.doi.org/10.1248/cpb.51.610.1248/cpb.51.6Search in Google Scholar

[30] A. S. Amin, J. Pharm. Biomed. Anal. 29, 729 (2002) http://dx.doi.org/10.1016/S0731-7085(02)00035-310.1016/S0731-7085(02)00035-3Search in Google Scholar

[31] H. Abdolahi, M.H. Sororaddin, A. Naseri, Anal. Sci. 22, 263 (2006) http://dx.doi.org/10.2116/analsci.22.26310.2116/analsci.22.263Search in Google Scholar

[32] Y-L. Chen, S-M. Wu, Anal. Bioanal. Chem. Sci. 381, 907 (2005) http://dx.doi.org/10.1007/s00216-004-2970-x10.1007/s00216-004-2970-xSearch in Google Scholar

[33] S. Dadashzadeh, A.M. Vall, N. Rezagholi, J. Pharm. Biomed. Anal. 28, 1201 (2002) http://dx.doi.org/10.1016/S0731-7085(02)00025-010.1016/S0731-7085(02)00025-0Search in Google Scholar

[34] P. Van Antwerpen, J. Dubois, M. Gelbcke, J. Neve, Free Radic. Res. 38, 251 (2004) http://dx.doi.org/10.1080/1071576031000165940410.1080/10715760310001659404Search in Google Scholar PubMed

[35] Lj. Kolar-Anić, Đ. Mišljenović, S. Anić, G. Nicolis, React. Kinet. Catal. Lett. 54, 35 (1995) http://dx.doi.org/10.1007/BF0207117810.1007/BF02071178Search in Google Scholar

Published Online: 2012-11-29
Published in Print: 2013-2-1

© 2013 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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