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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access November 29, 2012

Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

Gustavo Souza EMAIL logo , Mônica Rodrigues , Lucianno Fernandes , Priscila Silva , Reinaldo Ruggiero , Elene Pereira-Maia and Wendell Guerra
From the journal Open Chemistry


New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin.

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Published Online: 2012-11-29
Published in Print: 2013-2-1

© 2013 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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