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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access December 21, 2013

A low-cost automated flow analyzer based on low temperature co-fired ceramic and LED photometer for ascorbic acid determination

  • Osmundo Pessoa-Neto EMAIL logo , Vagner Santos , Fernando Vicentini , Willian Suarez , Julián Alonso-Chamarro , Orlando Fatibello-Filho and Ronaldo Faria
From the journal Open Chemistry


An automated flow analyzer based on low temperature co-fired ceramic (LTCC), a solid-phase reactor (SPR) and a low-cost photometer was designed for ascorbic acid (AA) determination in pharmaceutical formulations. It consists of a peristaltic pump, three-way solenoid valves, SPR to chemically convert Cu(II) into Cu(I), and a LTCC device for mixing the liberated copper with bathocuproine and detection. The flow cell in the LTCC employed an ultrabright LED — photodiode photometer. The analyzer successfully determined AA in pharmaceutical formulations. The analytical curve from 8.5×10−6 to 7.0×10−4 M gave a detection limit of 7.0×10−7 M and a RSD of 2.1% for a 2.0×10−4 M AA solution (n = 10). A high sampling frequency of 102 h−1 and low reagent and sample consumption (150 µL) resulted.

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Published Online: 2013-12-21
Published in Print: 2014-3-1

© 2014 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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