Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes

[1] Chitaley K., Type 1 and Type 2 diabetic-erectile dysfunction: same diagnosis (ICD-9), different disease?, J. Sex. Med., 2009, 6(Suppl.3), 262–268 http://dx.doi.org/10.1111/j.1743-6109.2008.01183.x10.1111/j.1743-6109.2008.01183.xSearch in Google Scholar

[2] Stiles M.C., Seaquist E.R., Cerebral structural and functional changes in type 1 diabetes, Minerva Med., 2010, 101, 105–114 Search in Google Scholar

[3] Tabit C.E., Chung W.B., Hamburg N.M., Vita J.A., Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications, Rev. Endocr. Metab. Disord., 2010, 11, 61–74 http://dx.doi.org/10.1007/s11154-010-9134-410.1007/s11154-010-9134-4Search in Google Scholar

[4] Hashim S., Li Y., Anand-Srivastava M.B., G proteinlinked cell signaling and cardiovascular functions in diabetes/hyperglycemia, Cell Biochem. Biophys., 2006, 44, 51–64 http://dx.doi.org/10.1385/CBB:44:1:05110.1385/CBB:44:1:051Search in Google Scholar

[5] Muniyappa R., Montagnani M., Koh K.K., Quon M.J., Cardiovascular actions of insulin, Endocr. Rev., 2007, 28, 463–491 http://dx.doi.org/10.1210/er.2007-000610.1210/er.2007-0006Search in Google Scholar

[6] Shpakov A.O., Kuznetsova L.A., Plesneva S.A., Gur’ianov I.A., Pertseva M.N., [Molecular causes of changes in sensitivity of adenylyl cyclase signaling system to biogenic amines in the heart muscle during experimental streptozotocin diabetes], Tsitologiia, 2005, 47, 540–548, (in Russian) Search in Google Scholar

[7] Shpakov A.O., Kuznetsova L.A., Plesneva S.A., Pertseva M.N., [The disturbance of the transduction of adenylyl cyclase inhibiting hormonal signal in myocardium and brain of rats with experimental type II diabetes], Tsitologiia, 2007, 49, 442–450, (in Russian) Search in Google Scholar

[8] Shpakov A.O., Derkach K.V., Bondareva V.M., [A decrease in the sensitivity of adenylyl cyclase and heterotrimeric G proteins to chorionic gonadotrophin and peptide hormones action in the tissues of reproductive system of rats with experimental type 2 diabetes], Biomed. Khim., 2010, 4, 258–263, (in Russian) 10.1134/S1990750810030078Search in Google Scholar

[9] Palmer T.M., Houslay M.D., Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice, Biochim. Biophys. Acta, 1991, 1097, 193–204 10.1016/0925-4439(91)90035-8Search in Google Scholar

[10] Weber L.P., Macleod K.M., Influence of streptozotocin diabetes on the Alpha-1 adrenoceptor and associated G proteins in rat arteries, J. Pharmacol. Exp. Ther., 1997, 283, 1469–1478 Search in Google Scholar

[11] Shpakov A.O., Bondareva V.M., Chistiakova O.V., [Functional state of adenylyl cyclase signaling system in reproductive tissues of rats with experimental type 1 diabetes], Tsitologiia, 2010, 52, 177–183, (in Russian) 10.1134/S1990519X10020112Search in Google Scholar

[12] Shpakov A.O., Kuznetsova L.A., Plesneva S.A., Kolychev A.P., Bondareva V.M., Chistyakova O.V., et al., Functional defects in adenylyl cyclase signaling mechanisms of insulin and relaxin action in skeletal muscles of rat with streptozotocin type 1 diabetes, Cent. Eur. J. Biol., 2006, 1, 530–544 http://dx.doi.org/10.2478/s11535-006-0035-110.2478/s11535-006-0035-1Search in Google Scholar

[13] Ovalle F., Clinical approach to the patient with diabetes mellitus and very high insulin requirements, Diabetes Res. Clin. Pract., 2010, 90, 231–242 http://dx.doi.org/10.1016/j.diabres.2010.06.02510.1016/j.diabres.2010.06.025Search in Google Scholar

[14] Mann D.M., Woodward M., Ye F., Krousel-Wood M., Muntner P., Trends in medication use among US adults with diabetes mellitus: glycemic control at the expense of controlling cardiovascular risk factors, Arch. Intern. Med., 2009, 169, 1718–1720 http://dx.doi.org/10.1001/archinternmed.2009.29610.1001/archinternmed.2009.296Search in Google Scholar PubMed

[15] Benedict C., Hallschmid M., Hatke A., Schultes B., Fehm H.L., Born J., et al., Intranasal insulin improves memory in humans, Psychoneuroendocrinology, 2004, 29, 1326–1334 http://dx.doi.org/10.1016/j.psyneuen.2004.04.00310.1016/j.psyneuen.2004.04.003Search in Google Scholar

[16] Stockhorst U., de Fries D., Steingrueber H.J., Scherbaum W.A., Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans, Physiol. Behav., 2004, 83, 47–54 10.1016/S0031-9384(04)00348-8Search in Google Scholar

[17] Hemmings S.J., Spafford D., Neonatal STZ model of type II diabetes mellitus in the Fischer 344 rat: characteristics and assessment of the status of the hepatic adrenergic receptors, Int. J. Biochem. Cell Biol., 2000, 32, 905–919 http://dx.doi.org/10.1016/S1357-2725(00)00019-410.1016/S1357-2725(00)00019-4Search in Google Scholar

[18] Blondel O., Bailbé D., Portha B., Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates, Diabetes, 1989, 38, 610–617 http://dx.doi.org/10.2337/diabetes.38.5.61010.2337/diabetes.38.5.610Search in Google Scholar

[19] Thorne R.G., Pronk G.J., Padmanabhan V., Frey W.H. 2nd, Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration, Neuroscience, 2004, 127, 481–496 http://dx.doi.org/10.1016/j.neuroscience.2004.05.02910.1016/j.neuroscience.2004.05.029Search in Google Scholar

[20] Baker S.P., Potter L.T., A minor component of the binding of [3H]guanyl-5′-yl imidodiphosphate to cardiac membranes associated with the activation of adenylyl cyclase, J. Biol. Chem., 1981, 256, 7925–7931 10.1016/S0021-9258(18)43367-4Search in Google Scholar

[21] Shpakov A.O., Shpakova E.A., Tarasenko I.I., Derkach K.V., Vlasov G.P., The peptides mimicking the third intracellular loop of 5-hydroxytryptamine receptors of the types 1B and 6 selectively activate G proteins and receptor-specifically inhibit serotonin signaling via the adenylyl cyclase system, Int. J. Pept. Res. Ther., 2010, 16, 95–105 http://dx.doi.org/10.1007/s10989-010-9208-x10.1007/s10989-010-9208-xSearch in Google Scholar

[22] Salomon Y., Londos C., Rodbell M.A., Highly sensitive adenylate cyclase assay, Anal. Biochem., 1974, 58, 541–548 http://dx.doi.org/10.1016/0003-2697(74)90222-X10.1016/0003-2697(74)90222-XSearch in Google Scholar

[23] McIntire W.E., MacCleery G., Garrison J.C., The G protein b subunit is a determinant in the coupling of Gs to the b1-adrenergic and A2a adenosine receptors, J. Biol. Chem., 2001, 276, 15801–15809 http://dx.doi.org/10.1074/jbc.M01123320010.1074/jbc.M011233200Search in Google Scholar PubMed

[24] Shpakov A.O., Kuznetsova L.A., Plesneva S.A., Bondareva V.M., Pertseva M.N., Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia, Bull. Exp. Biol. Med., 2007, 144, 684–688 http://dx.doi.org/10.1007/s10517-007-0405-310.1007/s10517-007-0405-3Search in Google Scholar PubMed

[25] Li Y., Descorbeth M., Anand-Srivastava M.B., Role of oxidative stress in high glucose-induced decreased expression of Giα proteins and adenylyl cyclase signaling in vascular smooth muscle cells, Am. J. Physiol. Heart Circ. Physiol., 2008, 294, 2845–2854 http://dx.doi.org/10.1152/ajpheart.91422.200710.1152/ajpheart.91422.2007Search in Google Scholar

[26] Bushfield M., Griffiths S.L., Murphy G.J., Pyne N.J., Knowler J.T., Milligan G., et al., Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes, Biochem. J., 1990, 271, 365–372 10.1042/bj2710365Search in Google Scholar

[27] Livingstone C., McLellan A.R., McGregor M.A., Wilson A., Connell J.M., Small M., et al., Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects, Biochim. Biophys. Acta., 1991, 1096, 127–133 10.1016/0925-4439(91)90050-JSearch in Google Scholar

[28] Caro J.F., Raju M.S., Caro M., Lynch C.J., Poulos J., Exton J.H., et al., Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: evidence for altered “cross-talk” between the insulin receptor and Giproteins, J. Cell. Biochem., 1994, 54, 309–319 http://dx.doi.org/10.1002/jcb.24054030710.1002/jcb.240540307Search in Google Scholar

[29] Gettys T.W., Ramkumar V., Surwit R.S., Taylor I.L., Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse, Metab. Clin. Exp., 1995, 44, 771–778 http://dx.doi.org/10.1016/0026-0495(95)90191-410.1016/0026-0495(95)90191-4Search in Google Scholar

[30] Hattori Y., Matsuda N., Sato A., Watanuki S., Tomioka H., Kawasaki H., et al., Predominant contribution of the G protein-mediated mechanism to NaF-induced vascular contractions in diabetic rats: association with an increased level of Gqα expression, J. Pharmacol. Exp. Ther., 2000, 292, 761–768 Search in Google Scholar

[31] Rodgers B.D., Bernier M., Levine M.A., Endocrine regulation of G-protein subunit production in an animal model of type 2 diabetes mellitus, J. Endocrinol., 2001, 168, 509–515 http://dx.doi.org/10.1677/joe.0.168050910.1677/joe.0.1680509Search in Google Scholar

[32] Hashim S., Li Y., Nagakura A., Takeo S., Anand-Srivastava M.B., Modulation of G-protein expression and adenylyl cyclase signaling by high glucose in vascular smooth muscle, Cardiovasc. Res., 2004, 63, 709–718 http://dx.doi.org/10.1016/j.cardiores.2004.04.02110.1016/j.cardiores.2004.04.021Search in Google Scholar

[33] Griffiths S.L., Knowler J.T., Houslay M.D., Diabetes-induced changes in guanine-nucleotide-regulatory-protein mRNA detected using synthetic oligonucleotide probes, Eur. J. Biochem., 1990, 193, 367–374 http://dx.doi.org/10.1111/j.1432-1033.1990.tb19348.x10.1111/j.1432-1033.1990.tb19348.xSearch in Google Scholar

[34] Lin S.L., Setya S., Johnson-Farley N.N., Cowen D.S., Differential coupling of 5-HT1 receptors to G proteins of the Gi family, Br. J. Pharmacol., 2002, 136, 1072–1078 http://dx.doi.org/10.1038/sj.bjp.070480910.1038/sj.bjp.0704809Search in Google Scholar

[35] Moller L.N., Stidsen C.E., Hartmann B., Holst J.J., Somatostatin receptors, Biochim. Biophys. Acta, 2003, 1616, 1–84 http://dx.doi.org/10.1016/S0005-2736(03)00235-910.1016/S0005-2736(03)00235-9Search in Google Scholar

[36] Robinson R., Krishnakumar A., Paulose C.S., Enhanced dopamine D1 and D2 receptor gene expression in the hippocampus of hypoglycaemic and diabetic rats, Cell. Mol. Neurobiol., 2009, 29, 365–372 http://dx.doi.org/10.1007/s10571-008-9328-410.1007/s10571-008-9328-4Search in Google Scholar PubMed

[37] Kumar T.P., Antony S., Gireesh G., George N., Paulose C.S., Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats, J. Biomed. Sci., 2010, http://www.jbiomedsci.com/content/17/1/43 10.1186/1423-0127-17-43Search in Google Scholar PubMed PubMed Central

[38] Hashim S., Liu Y.Y., Wang R., Anand-Srivastava M.B., Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle, Mol. Cell. Biochem., 2002, 240, 57–65 http://dx.doi.org/10.1023/A:102065252680310.1023/A:1020652526803Search in Google Scholar

[39] Bégin-Heick N., Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes, Am. J. Physiol., 1994, 266, 1664–1672 10.1152/ajpcell.1994.266.6.C1664Search in Google Scholar PubMed

[40] Uekita K., Tobise K., Onodera S., Enhancement of the cardiac β-adrenergic system at an early diabetic state in spontaneously diabetic Chinese hamsters, Jpn. Circ. J., 1997, 61, 64–73 http://dx.doi.org/10.1253/jcj.61.6410.1253/jcj.61.64Search in Google Scholar PubMed

[41] Dinçer U.D., Bidasee K.R., Güner S., Tay A., Ozçelikay A.T., Altan V.M., The effect of diabetes on expression of β1-, β2-, and β3-adrenoreceptors in rat hearts, Diabetes, 2001, 50, 455–461 http://dx.doi.org/10.2337/diabetes.50.2.45510.2337/diabetes.50.2.455Search in Google Scholar PubMed

[42] Bidasee K.R., Zheng H., Shao C.H., Parbhu S.K., Rozanski G.J., Patel K.P., Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of β-adrenoceptors, J. Appl. Physiol., 2008, 105, 907–914 http://dx.doi.org/10.1152/japplphysiol.00103.200810.1152/japplphysiol.00103.2008Search in Google Scholar PubMed PubMed Central

[43] Lahaye S.D., Gratas-Delamarche A., Malardé L., Vincent S., Zguira M.S., Morel S.L., et al., Intense exercise training induces adaptation in expression and responsiveness of cardiac β-adrenoceptors in diabetic rats, Cardiovasc. Diabetol., 2010, http://www.cardiab.com/content/9/1/72 10.1186/1475-2840-9-72Search in Google Scholar PubMed PubMed Central

[44] Atkins F.L., Dowell R.T., Love S., Beta-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat, J. Cardiovasc. Pharmacol., 1985, 7, 66–70 http://dx.doi.org/10.1097/00005344-198501000-0001110.1097/00005344-198501000-00011Search in Google Scholar PubMed

[45] Bilginoglu A., Cicek F.A., Ugur M., Gurdal H., Turan B., The role of gender differences in betaadrenergic receptor responsiveness of diabetic rat heart, Mol. Cell. Biochem., 2007, 305, 63–69 http://dx.doi.org/10.1007/s11010-007-9528-010.1007/s11010-007-9528-0Search in Google Scholar PubMed

[46] Gando S., Hattori Y., Akaishi Y., Nishihira J., Kanno M., Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: alterations in β adrenoceptors-G proteinadenylate cyclase system and phospholamban phosphorylation, J. Pharmacol. Exp. Ther., 1997, 282, 475–484 Search in Google Scholar

[47] Stanley W.C., Dore J.J., Hall J.L., Hamilton C.D., Pizzurro R.D., Roth D.A., Diabetes reduces right atrial β-adrenergic signaling but not agonist stimulation of heart rate in swine, Can. J. Physiol. Pharmacol., 2001, 79, 346–351 http://dx.doi.org/10.1139/y00-13310.1139/y00-133Search in Google Scholar

[48] Daniels A., van Bilsen M., Janssen B.J., Brouns A.E., Cleutjens J.P., Roemen T.H., et al., Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodeling, Acta Physiol. (Oxf), 2010, 200, 11–22 10.1111/j.1748-1716.2010.02102.xSearch in Google Scholar

[49] Tanaka Y., Kashiwagi A., Saeki Y., Shigeta Y., Abnormalities in cardiac α1-adrenoceptor and its signal transduction in streptozocin-induced diabetic rats, Am. J. Physiol., 1992, 263, 425–429 10.1152/ajpendo.1992.263.3.E425Search in Google Scholar

[50] Barber M., Kasturi B.S., Austin M.E., Patel K.P., MohanKumar S.M., MohanKumar P.S., Diabetesinduced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin, Brain Res., 2003, 964, 128–135 http://dx.doi.org/10.1016/S0006-8993(02)04091-X10.1016/S0006-8993(02)04091-XSearch in Google Scholar

[51] Hutchinson D.S., Summers R.J., Bengtsson T., Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease, Pharmacol. Ther., 2008, 119, 291–310 http://dx.doi.org/10.1016/j.pharmthera.2008.05.00810.1016/j.pharmthera.2008.05.008Search in Google Scholar

[52] Henkin R.I., Inhaled insulin-intrapulmonary, intranasal, and other routes of administration: mechanisms of action, Nutrition, 2010, 26, 33–39 http://dx.doi.org/10.1016/j.nut.2009.08.00110.1016/j.nut.2009.08.001Search in Google Scholar

[53] Gerozissis K., Brain insulin: regulation, mechanisms of action and functions, Cell. Mol. Neurobiol., 2003, 23, 1–25 http://dx.doi.org/10.1023/A:102259890024610.1023/A:1022598900246Search in Google Scholar

[54] Laron Z., Insulin and the brain, Arch. Physiol. Biochem., 2009, 115, 112–116 http://dx.doi.org/10.1080/1381345090294901210.1080/13813450902949012Search in Google Scholar

[55] Brüning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., et al., Role of brain insulin receptor in control of body weight and reproduction, Science, 2000, 289, 2122–2125 http://dx.doi.org/10.1126/science.289.5487.212210.1126/science.289.5487.2122Search in Google Scholar

[56] Hallschmid M., Benedict C., Born J., Fehm H.L., Kern W., Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man, Physiol. Behav., 2004, 83, 55–64 10.1016/S0031-9384(04)00349-XSearch in Google Scholar

[57] Biessels G.J., Deary I.J., Ryan C.M., Cognition and diabetes: a lifespan perspective, Lancet Neurol., 2008, 7, 184–190 http://dx.doi.org/10.1016/S1474-4422(08)70021-810.1016/S1474-4422(08)70021-8Search in Google Scholar

[58] Vig P.J., Subramony S.H., D’souza D.R., Wei J., Lopez M.E., Intranasal administration of IGF-I improves behavior and Purkinje cell pathology in SCA1 mice, Brain Res. Bull., 2006, 69, 573–579 http://dx.doi.org/10.1016/j.brainresbull.2006.02.02010.1016/j.brainresbull.2006.02.020Search in Google Scholar PubMed

[59] Benedict C., Hallschmid M., Schmitz K., Schultes B., Ratter F., Fehm H.L., et al., Intranasal insulin improves memory in humans: superiority of insulin aspart, Neuropsychopharmacology, 2007, 32, 239–243 http://dx.doi.org/10.1038/sj.npp.130119310.1038/sj.npp.1301193Search in Google Scholar PubMed