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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access March 27, 2009

Causes of death in HIV-infected patients in the region of Lodz, Poland from 1995 through 2005

Elżbieta Jabłonowska and Ewa Małolepsza
From the journal Open Medicine


In 2005, 440 patients infected with HIV were registered in the AIDS center in Lodz, Poland. The aim of our study was to analyze the causes of death in 70 fatal cases. We analyzed the data from 70 fatal cases from 1995 through 2005. Of the fatal cases we investigated, 10 were in women and 60 in men. The most common route of HIV transmission was intravenous drug use (50%). At the time of death, the mean age of patients was 36,48 years, and the mean CD4 count was 115,14 cells per microliter. The mean time from HIV diagnosis to death was 3,75 years. The leading cause of death in the group from 1995 through 2004 was AIDS. In 2002, liver diseases resulting from hepatitis C virus (HCV) infection were the cause of death in two patients. In 2005, two patients died as a result of myocardial infarction. The prevalence of fatal cases decreased from 9,09 % in 1995 to 1,59 % in 2005. Hepatitis B surface antigen (HBsAg) was found in 4 of 62 patients (6,45%), anti-HCV in 28 patients (45,16%), and both hepatitis B virus (HBV) and HCV infection in 5 patients (8,07%). Coinfections occurred most frequently in intravenous drug users (IDUs). In conclusions: (1) AIDS is still the leading cause of death in HIV-positive patients in the Lodz region; (2) the emerging cause of death in HIV-positive patients is liver disease as the sequel of HBV and HCV coinfections; (3) heart disease is becoming an important cause of death in HIV-positive patients.

[1] Crum N.F., Riffenburgh R.H., Wegner S., Agan B.K., Tasker S.A., Spooner K.M. et al., Comparisons of causes of death and mortality rates among HIV infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras, J. Acquir. Immune. Defic. Syndr., 2006, 41, 194–200. in Google Scholar

[2] Hogg R.S., O’shaughnessy M.V., Gataric N., et al., Decline in deaths from AIDS due to new antiretrovirals, Lancet, 1997, 349, 1294 in Google Scholar

[3] Jensen-Fangel S., Pedersen L., Pedersen C., Larsen C.S., Tauris P., Møller A., et al., Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population, AIDS, 2004, 18, 89–97 in Google Scholar

[4] Kumar A., Kilaru K.R., Forde S., Roach T.C., Changing HIV Infection-Related Mortality Rate and Causes of Death Among Persons With HIV Infection Before and After the Introduction of Highly Active Antiretroviral Therapy: Analysis of All HIV-Related Deaths in Barbados, 1997–2005, J. Int. Assoc. Physicians AIDS Care (Chic Ill), 2006, 5, 109–114 in Google Scholar

[5] Mocroft A., Ledergerber B., Katlama C., Kirk O., Reiss P., d’Arminio Monforte A., et al., Decline in the AIDS and death rates in the EuroSIDA study: an observational study, Lancet, 2003, 362, 22–29 in Google Scholar

[6] Moore R.D., Chaisson R.E., Natural history of HIV infection in the era of combination antiretroviral therapy, AIDS, 1999, 13, 1933–1942 in Google Scholar

[7] van Sighem A.I., van de Wiel M.A., Ghani A.C., Jambroes M., Reiss P., Gyssens I.C. et al., Mortality and progression to AIDS after starting highly active antiretroviral therapy, AIDS, 2003, 17, 2227–2236 in Google Scholar

[8] Sackoff J.E., Hanna D.B., Pfeiffer M.R., Torian L.V., Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City, Ann. Intern. Med., 2006, 145, 397–406 10.7326/0003-4819-145-6-200609190-00003Search in Google Scholar

[9] Cohen M.H., French A.L., Benning L., Kovacs A., Anastos K., Young M., et al., Causes of death among women with human immunodeficiency virus infection in the era of combination antiretroviral therapy, Am. J. Med., 2002, 113, 91–98 in Google Scholar

[10] Little S.J., Holte S., Routy J.P., Daar E.S., Markowitz M., Collier A.C., et al., Antiretroviral-drug resistance among patients recently infected with HIV, N. Engl. J. Med., 2002, 347, 385–394 in Google Scholar PubMed

[11] Krentz H.B., Kliewer G., Gill M.J., Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003, HIV Med., 2005, 6, 99–106 in Google Scholar PubMed

[12] Lewden C., Raffi F., Chêne G., Sobel A., Leport C., Mortality in a cohort of HIV-infected adults started on a protease inhibitor-containing therapy, J. Acquir. Immune. Defic. Syndr., 2001, 26, 480–482 10.1097/00042560-200104150-00013Search in Google Scholar

[13] Bica I., McGovern B., Dhar R., Stone D., McGowan K., Scheib R., et al., Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection, Clin. Infect. Dis., 2001, 32, 492–497 in Google Scholar PubMed

[14] Bonnet F., Lewden C., May T., Heripret L., Jougla E., Bevilacqua S., et al., Opportunistic infections as causes of death in HIV-infected patients in the HAART era in France, Scand. J. Infect. Dis., 2005, 37, 482–487 in Google Scholar PubMed

[15] Weber R., Sabin C.A., Friis-Moller N., Reiss P., El-Sadr W.M., Kirk O., et al., Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study, Arch. Intern. Med., 2006, 166, 1632–1641 in Google Scholar PubMed

[16] Sulkowski M.S., Thomas D.L., Chaisson R.E., Moore R.D., Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection, JAMA, 2000, 283, 74–80 in Google Scholar PubMed

[17] Jain M.K., Skiest D.J., Cloud J.W., Jain C.L., Burns D., Berggren R.E., Changes in mortality related to human immunodeficiency virus infection: comparative analysis of inpatient deaths in 1995 and in 1999–2000, Clin. Infect. Dis., 2003, 36, 1030–1038 in Google Scholar PubMed

[18] Lewden C., Bonnet F., Bevilacqua S. Heripret L., May T., Morlat P., et al., Causes of death in HIV-infected French drug users, 1995–2000, Ann. Med. Interne. (Paris), 2002, 153,7 Suppl., 2S4–2S10 Search in Google Scholar

[19] Rosenthal E., Poiree M., Pradier C. Perronne C., Salmon-Ceron D., Geffray L., et al., Mortality due to hepatitis C-related liver disease in HIV-infected patients in France (Mortavic 2001 study), AIDS, 2003, 17, 1803–1809 in Google Scholar PubMed

[20] Salmon-Ceron D., Lewden C., Morlat P. Bévilacqua S., Jougla E., Bonnet F., et al., Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol, J. Hepatol., 2005, 42, 799–805 in Google Scholar PubMed

Published Online: 2009-3-27
Published in Print: 2009-6-1

© 2009 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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