Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access April 17, 2010

Congenital heart disease and pulmonary tuberculosis

Rana Olguntürk, F.Sedef Tunaoğlu, Levent Gökgöz, Leyla Memiş and Serdar Kula
From the journal Open Medicine


A 13-year-old boy with atrial septal defect and tricuspid valve abnormality was reported. He had crepitan ralles and signs of heart failure. He was treated with digital, diuretic and antimicrobial therapies. After clinical improvement he underwent surgery. The atrial septal defect was closed, and ringplasty was applied to the tricuspid valve. After the operation, he could not be extubated because of respiratory failure. On the seventh day following the surgery, he developed pneumothorax and hyportension and died. Postmortem examination showed bilateral diffuse pulmonary tuberculosis. The aim of this report is to emphasise the association of tuberculosis and congenital heart disease.

[1] Mandalakas A.M., Starke J.R., Current concept of childhood tuberculosis, Semin. Pediatr. Infect. Dis., 2005, 16, 93–104 in Google Scholar

[2] Van der Merwe P.L., Kalis N., Schaaf H.S., Nel E.H., Gie R.P., Risk of pulmonary tuberculosis in children with congenital heart disease, Pediatr. Cardiol., 1995, 16, 172–5 10.1007/BF00794188Search in Google Scholar

[3] Ifere Q.A., Aikhionbare H.A., Yusuf U., Congenital heart disease masking pulmonary tuberculosis in children, East. Afr. Med. J., 1989, 66, 414–8 Search in Google Scholar

[4] Raviglione M.C., Snider D.E.J., Kochi A., Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic, JAMA., 1995,273, 220–6 in Google Scholar

[5] Kampmann B., Young D., Childhood tuberculosis: advances in immunopathogenesis, treatment and prevention, Curr. Opin. Infect. Dis., 1998,11, 331–5 10.1097/00001432-199806000-00011Search in Google Scholar

[6] Stead W.W., Senner J.W., Reddick W.T., Lofgren J.P., Racial differences in susceptibility to infection by mycobacterium tuberculosis, N. Eng. J. Med., 1990,322, 422–7 in Google Scholar

[7] Parisi M.T., Jensen M.C., Wood B.P., Pictorial review of the usual and unusual roentgen manifestations of childhood tuberculosis, Clin. Imag., 1994,18, 149–54 in Google Scholar

[8] Starke J.R., Jacobs R.F., Jereb J., Resurgence of tuberculosis in children, J. Pediatr., 1992,120, 839–55 in Google Scholar

[9] Tsao T.C, Juang Y.C., Tsai Y.H., Lan R.S., Lee C.H., Whole lung tuberculosis A disease with high mortality which is frequently misdiagnosed, Chest., 1992,101, 1309–11 in Google Scholar PubMed

[10] Starke J.R., Taylor-Watts K.T., Tuberculosis in the pediatric population of Houston, Texas, Pediatrics., 1989,84, 28–35 10.1542/peds.84.1.28Search in Google Scholar

[11] McMurray D.N., Mechanism of anergy in tuberculosis, Chest. 1980,77, 4–5 in Google Scholar PubMed

[12] Starke J.R., Childhood tuberculosis a diagnostic dilemma, Chest., 1993,104, 329–30 in Google Scholar

[13] Starke J.R., Pediatric tuberculosis: time for a new approach, Tuberculosis., 2003,83, 208–212 in Google Scholar

[14] Zar H.J., Hanslo D., Apolles P., Swingler G., Hussey G., Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study, Lancet., 2005,365,130–134 in Google Scholar

[15] Eamranond P., Jaramillo E., Tuberculosis in children: Reassessing the need for improved diagnosis in global control strategies, Int. J. Tuberc. Lung. Dis., 2001, 5, 594–603 Search in Google Scholar

[16] Shingadia D., Novelli V., Diagnosis and treatment of tuberculosis in children, Lancet. Infect. Dis., 2003, 3, 624–32 in Google Scholar

[17] Pomputius WF 3rd., Rost J., Dennehy P.H., Carter E.J., Standartization of gastric aspirate technique improves yield in the diagnosis of tuberculosis in children, Pediatr. Infect. Dis. J.,1997,16, 222–6 in Google Scholar

[18] Sarode V.R., Datta B.N., Banerjee A.K., Banerjee C.K., Joshi K., Bhusnurmath B., Radotra B.D. et al., Autopsy finding and clinical review of 1000 cases, Hum. Pathol., 1993,24, 194–8 in Google Scholar

Published Online: 2010-4-17
Published in Print: 2010-4-1

© 2009 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Scroll Up Arrow