Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access April 8, 2011

Sarcomatoid carcinoma of the urinary bladder and concomitant abdominal aortic aneurysm: a case report and literature review

Simona Francesco, Salvatore Magnasco and Raffaele Tenaglia
From the journal Open Medicine

Abstract

We report the diagnostic evaluation, management, and intermediate-term outcomes of a rare variant of bladder cancer and concomitant Abdominal Aortic Aneurysm. A 62 year old male with gross haematuria and Abdominal Aortic Aneurysm was admitted to our hospital. Cystoscopy revealed a large bulky mass occupying the posterior bladder wall. The tumor was transurethrally resected and its histology showed a Sarcomatoid Carcinoma of the urinary bladder. Due to the aggressive behavior of the tumor and the risk of aneurysm rupture, concomitant endovascular exclusion of Aneurysm, total cystectomy with urinary diversion was performed. 12 months after radical surgery the patient was alive without any local recurrence, distant metastasis, and thrombosis of iliac axis. To our knowledge this study is the first report to describe data on the diagnostic evaluation, Management, and intermediate-term outcomes in Sarcomatoid carcinoma and Concomitant Abdominal Aortic Aneurysm. Multi-institutional collaboration is important to perform clinical trials of adequate sample size to design more effective treatments for these aggressive cancers in the presence of Concomitant Abdominal Aortic Aneurysm.

[1] Dahm P., Gschwend J. E. Malignant Non-Urothelial Neoplasms of the Urinary Bladder: A Review. Eur Urol 2003; 44: 672–681 http://dx.doi.org/10.1016/S0302-2838(03)00416-010.1016/S0302-2838(03)00416-0Search in Google Scholar

[2] Torenbeek R., Blomjous C. M., De Bruin P. C., Newling D. W., Meijer C. J.: Sarcomatoid carcinoma of the urinary bladder. Am. J. Surg. Pathol. 1994; 18:241 http://dx.doi.org/10.1097/00000478-199403000-0000310.1097/00000478-199403000-00003Search in Google Scholar

[3] Lopez-Beltran A., Pacelli A, Rothenberg H. J. et al. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 Cases. J Urol. 1998; 159:1497–1503 http://dx.doi.org/10.1097/00005392-199805000-0002310.1097/00005392-199805000-00023Search in Google Scholar

[4] Ikegami H., Iwasaki H., Ohjimi Y., Takeuchi T., Ariyoshi A., Kikuchi M. Sarcomatoid carcinoma of the Urinary Bladder: a clinicopathologic and immunohistochemical analysis of 14 Patients. Hum Pathol 2000; 31:332–340 http://dx.doi.org/10.1016/S0046-8177(00)80247-610.1016/S0046-8177(00)80247-6Search in Google Scholar

[5] Antonelli A., Simeone C., Ferrari V., Tardanico R., Cunico Cosciani S. Durable and complete remission of a metastatic bladder sarcomatoid carcinoma with chemotherapic and surgical treatments. Arch. Ital. Urol. Androl. 2006; 78:67–70 Search in Google Scholar

[6] Lopez-Beltran A., Requena M. J., Cheng L., Montironi R. Pathological variants of invasive bladder cancer according to their suggested clinical significance BJU Int. 2008; 101:275–281 http://dx.doi.org/10.1111/j.1464-410X.2007.07271.x10.1111/j.1464-410X.2007.07271.xSearch in Google Scholar PubMed

[7] Sung M. T., Wang M., MacLennan G.T. et al. Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: evidence for a common clonal origin with divergent differentiation J Pathol. 2007; 211:420–430 http://dx.doi.org/10.1002/path.212910.1002/path.2129Search in Google Scholar PubMed

[8] Lopez-Beltran A., Requena M. J., Liang C. and Montironi R. Pathological variants of invasive bladder cancer according to their suggested clinical significance. BJU Int. 2007; 101:275–281 http://dx.doi.org/10.1111/j.1464-410X.2007.07271.x10.1111/j.1464-410X.2007.07271.xSearch in Google Scholar

[9] Arenas L. F., Fontes D. A., Pereira E. M., Hering F. L. Sarcomatoid carcinoma with osseous differentiation in the bladder Int. Braz J Urol 2006; 32:563–565 10.1590/S1677-55382006000500010Search in Google Scholar

[10] Black P. C., Brown G. A., Dinney C. P, The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol. Oncol 2009; 27:3–7 Search in Google Scholar

[11] Pagano S., Ruggeri P., Franzoso F., Brusamolino R., Unusual renal cell carcinoma metastasis to the gallbladder Urol. 1995; 45:867–869 Search in Google Scholar

[12] Grego F., Lepidi S., Bassi P. et al. Simultaneous surgical treatment of abdominal aortic aneurysm and carcinoma of the bladder. J Vasc Surg 2003; 37:607–614 http://dx.doi.org/10.1067/mva.2003.2610.1067/mva.2003.26Search in Google Scholar PubMed

[13] Mearini L., Zucchi A., Pizzirusso G., Vivaacqua C., Mearini L. Incidence and evolution of aortic aneurysm in patient with bladder cancer Arch. Ital. Urol. Androl. 2004; 76:80–82 Search in Google Scholar

Published Online: 2011-4-8
Published in Print: 2011-6-1

© 2011 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Scroll Up Arrow