Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access August 9, 2011

Sudden onset blindness treated with pulse steroid therapy in a patient with microscopic polyangiitis

  • Yoshiro Horai EMAIL logo , Tomoya Miyamura , Karin Shimada , Soichiro Takahama , Rumi Minami , Masahiro Yamamoto and Eiichi Suematsu
From the journal Open Medicine


We report a 71-year-old male with microscopic polyangiitis (MPA) who developed sudden-onset, progressive, bilateral visual loss associated with a relapse of MPA symptoms. The patient was referred to our hospital, and treated with intravenous pulse steroid therapy and high-dose oral prednisolone. Although the right eye remained vision deficient, visual acuity in the left eye recovered. Ocular manifestations of MPA are quite uncommon. This case emphasizes the necessity of early detection and initiation of prompt therapy where ocular manifestations of MPA occur.

[1] Rarok AA, Limburg PC, Kallenberg CG. Neutrophilactivating potential of antineutrophil cytoplasm autoantibodies. J Leukoc Biol, 2003, 7, 3–15 in Google Scholar PubMed

[2] Guillevin L, Durand-Gasselin B, Cevallos R, et al. Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. Arthritis Rheum, 1999, 42, 421–430<421::AID-ANR5>3.0.CO;2-610.1002/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6Search in Google Scholar

[3] Yoshida M. Clinical analysis of anti-neutrophil cytoplasmic antibody in diagnosis of collagen diseases. Nippon Naika Gakkai Zasshi(Japanese). 2003, 92, 1941–1947 in Google Scholar

[4] Tamura N, Matsudaira R, Hirashima M, et al. Two cases of refractory Wegener’s granulomatosis successfully treated with rituximab. Intern Med, 2007, 46:409–414 in Google Scholar

[5] Duran E, Merkel PA, Sweet S, Swan N, Babikian VL. ANCA-associated small vessel vasculitis presenting with ischemic optic neuropathy. Neurology, 2004, 62, 152–153 10.1212/WNL.62.1.152Search in Google Scholar

[6] Altaie R, Ditizio F, Fahy GT. Microscopic polyangitis presenting with sub-acute reversible optic neuropathy. Eye, 2004, 19, 363–365 in Google Scholar

Published Online: 2011-8-9
Published in Print: 2011-10-1

© 2011 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 23.2.2024 from
Scroll to top button