Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access March 29, 2012

B-cell activating factor (BAFF) — a new factor linking immunity to diet?

  • Julie Bienertova-Vasku EMAIL logo , Petr Bienert , Filip Zlamal , Josef Tomandl , Martin Forejt , Marie Tomandlova , Martin Vavrina , Jana Kudelková , Zbynek Splichal and Anna Vasku
From the journal Open Medicine

Abstract

B cell activation factor (BAFF) is a recently discovered member of the TNF ligand superfamily secreted by adipocytes, previously linked to autoimmune and lymphoproliferative disease. The aim of this study was to investigate the relationship between BAFF plasma levels and the non-modified, usual dietary composition as well as obesity-related anthropometric parameters in a cohort of 58 obese and non-obese Central-European Caucasian individuals. We found that BAFF had an independent predictive role for percentage of body fat; moreover, BAFF levels were correlated with waist and hip circumference. BAFF plasma levels were also significantly correlated with investigated dietary composition based on the 7-day food records, as the BAFF levels correlated with the percentage of energy derived from the carbohydrates and with energy derived from the dietary fat. Our results suggest that BAFF may play a role in linking the immune status and metabolic response to diet.

[1] Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, Giri J, Roschke V, Nardelli B, Carrell J, Sosnovtseva S, Greenfield W, Ruben SM, Olsen HS, Fikes J, Hilbert DM. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260–263 http://dx.doi.org/10.1126/science.285.5425.26010.1126/science.285.5425.260Search in Google Scholar PubMed

[2] Nardelli B, Belvedere O, Roschke V, Moore PA, Olsen HS, Migone TS, Sosnovtseva S, Carrell JA, Feng P, Giri JG, Hilbert DM. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 2001;97(1):198–204 http://dx.doi.org/10.1182/blood.V97.1.19810.1182/blood.V97.1.198Search in Google Scholar

[3] Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2002;2:465–475 http://dx.doi.org/10.1038/nri84410.1038/nri844Search in Google Scholar PubMed

[4] Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 2001;293:2108–2111 http://dx.doi.org/10.1126/science.106196510.1126/science.1061965Search in Google Scholar PubMed

[5] Novak AJ, Bram RJ, Kay NE, Jelinek DF. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 2002;100:2973–2979 http://dx.doi.org/10.1182/blood-2002-02-055810.1182/blood-2002-02-0558Search in Google Scholar PubMed

[6] Scapini P, Nardelli B, Nadali G, Calzetti F, Pizzolo G, Montecucco C, Cassatella MA. G-CSF stimulated neutrophils are a prominent source of functional. BLyS J Exp Med 2003;197:297–302 http://dx.doi.org/10.1084/jem.2002134310.1084/jem.20021343Search in Google Scholar PubMed PubMed Central

[7] Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X. Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren’s syndrome. J Pathol 2004;202:496–502 http://dx.doi.org/10.1002/path.153310.1002/path.1533Search in Google Scholar PubMed

[8] Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu CM, Kalled SL, Hess DM, Serafini B, Aloisi F, Wekerle H, Hohlfeld R, Meinl E. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 2005;201:195–200 http://dx.doi.org/10.1084/jem.2004167410.1084/jem.20041674Search in Google Scholar PubMed PubMed Central

[9] Huard B, Arlettaz L, Ambrose C, Kindler V, Mauri D, Roosnek E, Tschopp J, Schneider P, French LE. BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol 2004;16:467–475 http://dx.doi.org/10.1093/intimm/dxh04310.1093/intimm/dxh043Search in Google Scholar PubMed

[10] Zhang J, Roschke V, Baker KP, Wang Z, Alarcón GS, Fessler BJ, Bastian H, Kimberly RP, Zhou T. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol 2001;166:6–10 10.4049/jimmunol.166.1.6Search in Google Scholar PubMed

[11] Kim YH, Choi BH, Cheon HG, Do MS. B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation. Exp Mol Med 2009;41(3):208–216 http://dx.doi.org/10.3858/emm.2009.41.3.02410.3858/emm.2009.41.3.024Search in Google Scholar PubMed PubMed Central

[12] Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 2009;183(9):5948–5956 http://dx.doi.org/10.4049/jimmunol.090118610.4049/jimmunol.0901186Search in Google Scholar PubMed

[13] Fabris M, Visentini D, De Re V, Picierno A, Maieron R, Cannizzaro R, Villalta D, Curcio F, De Vita S, Tonutti E. Elevated B cell-activating factor of the tumour necrosis factor family in coeliac disease. Scand J Gastroenterol. 2007;42(12):1434–1439 http://dx.doi.org/10.1080/0036552070145222510.1080/00365520701452225Search in Google Scholar PubMed

[14] Jee HM, Kim KW, Hong JY, Sohn MH, Kim KE. Increased serum B cell-activating factor level in children with atopic dermatitis. Clin Exp Dermatol. 2010;35(6):593–598 http://dx.doi.org/10.1111/j.1365-2230.2009.03635.x10.1111/j.1365-2230.2009.03635.xSearch in Google Scholar PubMed

[15] Agus MS, Swain JF, Larson CL, Eckert EA, Ludwig DS. Dietary composition and physiologic adaptations to energy restriction. Am J Clin Nutr 2000;71(4):901–907 10.1093/ajcn/71.4.901Search in Google Scholar PubMed PubMed Central

[16] La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004;4: 371–379 http://dx.doi.org/10.1038/nri135010.1038/nri1350Search in Google Scholar PubMed

[17] Bienertová-Vasků J, Bienert P, Forejt M, Tomandl J, Brázdová Z, Vasků A. A genotype x nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. Br J Nutr 2010;103(3):352–359 http://dx.doi.org/10.1017/S000711450999188710.1017/S0007114509991887Search in Google Scholar PubMed

[18] Ma Y, Bertone ER, Stanek EJ 3rd, Reed GW, Hebert JR, Cohen NL, Merriam PA, Ockene IS. Association between eating patterns and obesity in a free-living US adult population. Am J Epidemiol 2003;158:85–92 http://dx.doi.org/10.1093/aje/kwg11710.1093/aje/kwg117Search in Google Scholar PubMed

[19] Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE. Reproducibility and Validity of A Semiquantitative Food Frequency Questionnaire. Am J Epidemiol 1985;122: 51–65 10.1093/oxfordjournals.aje.a114086Search in Google Scholar PubMed

[20] Boylan S, Welch A, Pikhart H, Malyutina S, Pajak A, Kubinova R, Bragina O, Simonova G, Stepaniak U, Gilis-Januszewska A, Milla L, Peasey A, Marmot M, Bobak M. Dietary habits in three Central and Eastern European countries: the HAPIEE study. BMC Public Health 2009;1;9: 439 http://dx.doi.org/10.1186/1471-2458-9-43910.1186/1471-2458-9-439Search in Google Scholar PubMed PubMed Central

[21] Fabris M, De Vita S, Visentini D, Fabro C, Picierno A, Lerussi A, Villalta D, Alessio MG, Tampoia M, Tonutti E. B-lymphocyte stimulator and a proliferation-inducing ligand serum levels in IgA-deficient patients with and without celiac disease. Ann N Y Acad Sci. 2009;1173:268–273 http://dx.doi.org/10.1111/j.1749-6632.2009.04628.x10.1111/j.1749-6632.2009.04628.xSearch in Google Scholar PubMed

[22] Hamada M, Abe M, Miyake T, Kawasaki K, Tada F, Furukawa S, Matsuura B, Hiasa Y, Onji M. B cell-activating factor controls the production of adipokines and induces insulin resistance. Obesity (Silver Spring). 2011;19(10):1915–1922 http://dx.doi.org/10.1038/oby.2011.16510.1038/oby.2011.165Search in Google Scholar PubMed

[23] Ota M, Duong BH, Torkamani A, Doyle CM, Gavin AL, Ota T, Nemazee D. Regulation of the B Cell Receptor Repertoire and Self-Reactivity by BAFF. J Immunol. 2010;185(7):4128–4136 http://dx.doi.org/10.4049/jimmunol.100217610.4049/jimmunol.1002176Search in Google Scholar PubMed PubMed Central

[24] Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 2006;25(3):403–415 http://dx.doi.org/10.1016/j.immuni.2006.07.01010.1016/j.immuni.2006.07.010Search in Google Scholar PubMed

[25] Fabris M, Quartuccio L, Sacco S, De Marchi G, Pozzato G, Mazzaro C, Ferraccioli G, Migone TS, De Vita S. B-Lymphocyte stimulator (BLyS) up-regulation in mixed cryoglobulinaemia syndrome and hepatitis-C virus infection. Rheumatology (Oxford) 2007;46(1):37–43 http://dx.doi.org/10.1093/rheumatology/kel17410.1093/rheumatology/kel174Search in Google Scholar PubMed

[26] Harris RB, Bowen HM, Mitchell TD. Leptin resistance in mice is determined by gender and duration of exposure to high-fat diet. Physiol Behav 2003;78(4-5):543–555 http://dx.doi.org/10.1016/S0031-9384(03)00035-010.1016/S0031-9384(03)00035-0Search in Google Scholar

[27] Della-Fera MA, Li C, Baile CA. Resistance to IP leptin-induced adipose apoptosis caused by high-fat diet in mice. Biochem Biophys Res Commun 2003;303(4):1053–1057 http://dx.doi.org/10.1016/S0006-291X(03)00474-110.1016/S0006-291X(03)00474-1Search in Google Scholar

[28] Prpic V, Watson PM, Frampton IC, Sabol MA, Jezek GE, Gettys TW. Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity. Endocrinology 2003;144:1155–1163 http://dx.doi.org/10.1210/en.2002-22083510.1210/en.2002-220835Search in Google Scholar PubMed

[29] Münzberg H, Flier JS, Bjørbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880–4889 http://dx.doi.org/10.1210/en.2004-072610.1210/en.2004-0726Search in Google Scholar PubMed

[30] Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006;176(12):7745–7752 10.4049/jimmunol.176.12.7745Search in Google Scholar PubMed

Published Online: 2012-3-29
Published in Print: 2012-6-1

© 2012 Versita Warsaw

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 11.12.2023 from https://www.degruyter.com/document/doi/10.2478/s11536-011-0153-7/html
Scroll to top button