Abstract
Many diffusion tensor tractography (DTT) studies have reported on the topography of transcallosal fibers (TCF). However, little detailed anatomical information on TCF that can be easily applied for clinical purposes is known. Using probabilistic DTT, we attempted to determine the anatomical location of the TCF for motor and sensory function in the human brain. A total of 51 healthy subjects were recruited for this study. Diffusion tensor images (DTIs) were obtained at 1.5 T, and four TCF for the premotor cortex (PMC), the primary motor cortex (M1) for hand and leg, and the primary somatosensory cortex (S1) were obtained using FMRIB software. Locations of the TCF were defined as the highest probabilistic location on the midsagittal slice of the corpus callosum. We measured distances between the most anterior and posterior points of the corpus callosum. The relative mean distances of the highest probabilistic location for the precentral knob PMC (Brodmann area 6 anterior to the precentral knob), hand M1, leg M1, and precentral knob S1 (postcentral gyrus posterior to the precentral knob) TCF were 48.99%, 59.78%, 67.93%, and 73,48% from the most anterior point of the CC, respectively. According to our findings, the precentral knob PMC, hand M1, leg M1, and precentral knob S1 TCF were located at the anterior body, posterior body, posterior body, and isthmus according to Witelson’s classification, respectively.
[1] Jones E.G., Epilepsy and the corpus callosum, Plenum Press, New York, 1985 Search in Google Scholar
[2] Wahl M., Ziemann U., The human motor corpus callosum, Rev. Neurosci., 2008, 19, 451–466 10.1515/REVNEURO.2008.19.6.451Search in Google Scholar PubMed
[3] Watson R.T., Heilman K.M., Callosal apraxia, Brain, 1983, 106, 391–403 http://dx.doi.org/10.1093/brain/106.2.39110.1093/brain/106.2.391Search in Google Scholar PubMed
[4] Bogousslavsky J., Caplan L.R., Stroke syndromes, Cambridge University Press, Cambridge, 2001 http://dx.doi.org/10.1017/CBO978051158652110.1017/CBO9780511586521Search in Google Scholar
[5] Bourekas E.C., Varakis K., Bruns D., Christoforidis G.A., Baujan M., Slone H.W., et al., Lesions of the corpus callosum: MR imaging and differential considerations in adults and children, AJR Am. J. Roentgenol., 2002, 179, 251–257 http://dx.doi.org/10.2214/ajr.179.1.179025110.2214/ajr.179.1.1790251Search in Google Scholar PubMed
[6] Jea A., Vachhrajani S., Widjaja E., Nilsson D., Raybaud C., Shroff M., et al., Corpus callosotomy in children and the disconnection syndromes: a review, Childs Nerv. Syst., 2008, 24, 685–692 http://dx.doi.org/10.1007/s00381-008-0626-410.1007/s00381-008-0626-4Search in Google Scholar PubMed
[7] Blume W.T., Corpus callosum section for seizure control: rationale and review of experimental and clinical data, Cleve. Clin. Q., 1984, 51, 319–332 http://dx.doi.org/10.3949/ccjm.51.2.31910.3949/ccjm.51.2.319Search in Google Scholar PubMed
[8] Molko N., Cohen L., Mangin J.F., Chochon F., Lehericy S., Le Bihan D., et al., Visualizing the neural bases of a disconnection syndrome with diffusion tensor imaging, J. Cogn. Neurosci., 2002, 14, 629–636 http://dx.doi.org/10.1162/0898929026004586410.1162/08989290260045864Search in Google Scholar PubMed
[9] Le T.H., Mukherjee P., Henry R.G., Berman J.I., Ware M., Manley G.T., Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: an imaging correlate for the posterior callosal “disconnection” syndrome: case report, Neurosurgery, 2005, 56, 189 10.1227/01.NEU.0000144846.00569.3ASearch in Google Scholar PubMed
[10] Lin F., Yu C., Liu Y., Li K., Lei H., Diffusion tensor group tractography of the corpus callosum in clinically isolated syndrome, AJNR Am. J. Neuroradiol., 2011, 32, 92–98 http://dx.doi.org/10.3174/ajnr.A260210.3174/ajnr.A2602Search in Google Scholar PubMed PubMed Central
[11] Chang M.C., Yeo S.S., Jang S.H., Callosal disconnection syndrome in a patient with corpus callosum hemorrhage: a diffusion tensor tractography study, Arch. Neurol., 2012, 69: 1374–1375 http://dx.doi.org/10.1001/archneurol.2012.4810.1001/archneurol.2012.48Search in Google Scholar PubMed
[12] Abe O., Masutani Y., Aoki S., Yamasue H., Yamada H., Kasai K., et al., Topography of the human corpus callosum using diffusion tensor tractography, J. Comput. Assist. Tomogr., 2004, 28, 533–539 http://dx.doi.org/10.1097/00004728-200407000-0001610.1097/00004728-200407000-00016Search in Google Scholar
[13] Hofer S., Frahm J., Topography of the human corpus callosum revisited -comprehensive fiber tractography using diffusion tensor magnetic resonance imaging, Neuroimage, 2006, 32, 989–994 http://dx.doi.org/10.1016/j.neuroimage.2006.05.04410.1016/j.neuroimage.2006.05.044Search in Google Scholar
[14] Zarei M., Johansen-Berg H., Smith S., Ciccarelli O., Thompson A.J., Matthews P.M., Functional anatomy of interhemispheric cortical connections in the human brain, J. Anat., 2006, 209, 311–320 http://dx.doi.org/10.1111/j.1469-7580.2006.00615.x10.1111/j.1469-7580.2006.00615.xSearch in Google Scholar
[15] Wahl M., Lauterbach-Soon B., Hattingen E., Jung P., Singer O., Volz S., et al., Human motor corpus callosum: topography, somatotopy, and link between microstructure and function, J. Neurosci., 2007, 27, 12132–12138 http://dx.doi.org/10.1523/JNEUROSCI.2320-07.200710.1523/JNEUROSCI.2320-07.2007Search in Google Scholar
[16] Park H.J., Kim J.J., Lee S.K., Seok J.H., Chun J., Kim D.I., et al., Corpus callosal connection mapping using cortical gray matter parcellation and DT-MRI, Hum. Brain Mapp., 2008, 29, 503–516 http://dx.doi.org/10.1002/hbm.2031410.1002/hbm.20314Search in Google Scholar
[17] Chao Y.P., Cho K.H., Yeh C.H., Chou K.H., Chen J.H., Lin C.P., Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and high angular resolution diffusion imaging tractography, Hum. Brain Mapp., 2009, 30, 3172–3187 http://dx.doi.org/10.1002/hbm.2073910.1002/hbm.20739Search in Google Scholar
[18] Koerte I., Heinen F., Fuchs T., Laubender R.P., Pomschar A., Stahl R., et al., Anisotropy of callosal motor fibers in combination with transcranial magnetic stimulation in the course of motor development, Invest. Radiol., 2009, 44, 279–284 http://dx.doi.org/10.1097/RLI.0b013e31819e936210.1097/RLI.0b013e31819e9362Search in Google Scholar
[19] Salvolini U., Polonara G., Mascioli G., Fabri M., Manzoni T., Functional topography of the human corpus callosum, Bull. Acad. Natl. Med., 2010, 194, 617–631; discussion 631–632 10.1016/S0001-4079(19)32304-0Search in Google Scholar
[20] Fabri M., Polonara G., Mascioli G., Salvolini U., Manzoni T., Topographical organization of human corpus callosum: an fMRI mapping study, Brain Res., 2011, 1370, 99–111 http://dx.doi.org/10.1016/j.brainres.2010.11.03910.1016/j.brainres.2010.11.039Search in Google Scholar PubMed
[21] Gawryluk J.R., D’Arcy R.C., Mazerolle E.L., Brewer K.D., Beyea S.D., Functional mapping in the corpus callosum: a 4T fMRI study of white matter, Neuroimage, 2011, 54, 10–15 http://dx.doi.org/10.1016/j.neuroimage.2010.07.02810.1016/j.neuroimage.2010.07.028Search in Google Scholar PubMed
[22] Fling B.W., Benson B.L., Seidler R.D., Transcallosal sensorimotor fiber tract structure-function relationships, Hum. Brain Mapp., 2013, 34, 384–395 http://dx.doi.org/10.1002/hbm.2143710.1002/hbm.21437Search in Google Scholar PubMed PubMed Central
[23] Behrens T.E., Johansen-Berg H., Woolrich M.W., Smith S.M., Wheeler-Kingshott C.A., Boulby P.A., et al., Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging, Nat. Neurosci., 2003, 6, 750–757 http://dx.doi.org/10.1038/nn107510.1038/nn1075Search in Google Scholar PubMed
[24] Smith S.M., Jenkinson M., Woolrich M.W., Beckmann C.F., Behrens T.E., Johansen-Berg H., et al., Advances in functional and structural MR image analysis and implementation as FSL, Neuroimage, 2004, 23Suppl. 1, S208–219 http://dx.doi.org/10.1016/j.neuroimage.2004.07.05110.1016/j.neuroimage.2004.07.051Search in Google Scholar PubMed
[25] Behrens T.E., Berg H.J., Jbabdi S., Rushworth M.F., Woolrich M.W., Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?, Neuroimage, 2007, 34, 144–155 http://dx.doi.org/10.1016/j.neuroimage.2006.09.01810.1016/j.neuroimage.2006.09.018Search in Google Scholar PubMed PubMed Central
[26] Hong J.H., Son S.M., Jang S.H., Somatotopic location of corticospinal tract at pons in human brain: a diffusion tensor tractography study, Neuroimage, 2010, 51, 952–955 http://dx.doi.org/10.1016/j.neuroimage.2010.02.06310.1016/j.neuroimage.2010.02.063Search in Google Scholar PubMed
[27] Witelson S.F., Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study, Brain, 1989, 112, 799–835 http://dx.doi.org/10.1093/brain/112.3.79910.1093/brain/112.3.799Search in Google Scholar PubMed
[28] Wiegell M.R., Larsson H.B., Wedeen V.J., Fiber crossing in human brain depicted with diffusion tensor MR imaging, Radiology, 2000, 217, 897–903 10.1148/radiology.217.3.r00nv43897Search in Google Scholar PubMed
[29] Parker G.J., Alexander D.C., Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue, Philos. Trans. R. Soc. Lond. B Biol. Sci., 2005, 360, 893–902 http://dx.doi.org/10.1098/rstb.2005.163910.1098/rstb.2005.1639Search in Google Scholar PubMed PubMed Central
[30] Yamada K., Sakai K., Akazawa K., Yuen S., Nishimura T., MR tractography: a review of its clinical applications, Magn. Reson. Med. Sci., 2009, 8, 165–174 http://dx.doi.org/10.2463/mrms.8.16510.2463/mrms.8.165Search in Google Scholar PubMed
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