Abstract
As a result of growing awareness, consumers are increasingly interested in products that are safe on the skin and environmentally-friendly. This is one of the most important reasons for the very rapid development of the natural cosmetics segment which has been observed for several years now. Among the most commonly used anionic surfactants of natural origin are sodium lauryl sulfate (SLS) and sodium coco sulfate (SCS). As there are no unambiguous reports on the safety of using SCS, in this study an attempt was made to evaluate the effect of SCS on the skin. The results of the determination of the skin irritation potential (zein value) indicate that the analyzed parameter is approximately 15 % lower in SCS than in SLS. SCS has a stronger ability to interact with epidermal lipids and cause their elution from the skin, which in turn may damage the protective epidermal barrier. The results obtained during the evaluation of the effect produced by the analyzed substances on the metabolism of human keratinocytes (HaCaT) show that after 4 h of incubation with the studied groups of compounds there was a significant decrease in cell proliferation. The highest decrease in cell metabolism was demonstrated for SLS.
Kurzfassung
Aufgrund eines wachsenden Bewusstseins interessieren sich die Verbraucher zunehmend für Produkte, die sicher auf der Haut und umweltfreundlich sind. Dies ist einer der wichtigsten Gründe für die seit einigen Jahren beobachtete sehr schnelle Entwicklung des Naturkosmetiksegments. Zu den am häufigsten verwendeten anionischen Tensiden natürlichen Ursprungs zählen Natriumlaurylsulfat (SLS) und Natriumkokosulfat (SCS). Da keine eindeutigen Berichte über die Sicherheit der Verwendung von SCS vorliegen, wurde in dieser Studie versucht, die Wirkung von SCS auf die Haut zu bewerten. Die Ergebnisse der Bestimmung des Hautreizungspotenzials (Zein-Wert) weisen darauf hin, dass der analysierte Parameter bei SCS ca. 15 % niedriger ist als bei SLS. SCS kann stärker mit epidermalen Lipiden interagieren und diese besser von der Haut eluieren, was wiederum die schützende epidermale Barriere beschädigen kann. Die Ergebnisse, die bei der Bewertung des Effekts der analysierten Substanzen auf den Metabolismus menschlicher Keratinozyten (HaCaT) erhalten wurden, zeigen, dass nach 4 Stunden Inkubation mit den untersuchten Verbindungsgruppen eine signifikante Abnahme der Zellproliferation auftrat. Die höchste Abnahme des Zellstoffwechsels wurde für SLS nachgewiesen.
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