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Licensed Unlicensed Requires Authentication Published by De Gruyter June 18, 2020

Self-Assembly, Interfacial, and Thermodynamic Properties of Antipsychotic Drug with Bile Salt in Water/Salt Solutions

Selbstorganisation, grenzflächenbezogene und thermodynamische Eigenschaften von Antipsychotika mit Gallensalz in Wasser/Salzlösungen
  • Naved Azum , Malik Abdul Rub and Abdullah M. Asiri


Herein, we investigated the micelle formation of mixed systems of the antipsychotic drug, chlorpromazine hydrochloride (CPZ), and the bile salt, sodium deoxycholate (NaDC), both in the absence and presence of NaCl by tensiometry. To understand the aggregation behaviour of the mixture of these two amphiphiles, we calculated various micellar and interfacial parameters using the theories of Clint, Rubingh, Rosen and Motomura. The calculated interaction parameters indicate an attractive interaction between the two amphiphiles both in the absence and presence of salt. The results were discussed with regard to the use of bile salt as a promising drug carrier for CPZ and the improvement of its bioavailability.


Wir untersuchten die Mizellenbildung von Mischsystemen aus dem antipsychotischem Arzneiwirkstoff Chlorpromazinhydrochlorid (Chlorpromazin, CPZ) und dem Gallensalz Natriumdesoxycholat (NaDC) sowohl in Abwesenheit als auch in Anwesenheit von NaCl mittels Tensiometrie. Um das Aggregationsverhalten der Mischung aus diesen beiden Amphiphilen zu verstehen, berechneten wir verschiedene mizellare und grenzflächenbezogene Parameter unter Verwendung der Theorien von Clint, Rubingh, Rosen und Motomura. Die berechneten Wechselwirkungsparameter weisen auf eine attraktive Wechselwirkung zwischen den zwei Amphiphilen sowohl bei Abwesenheit als auch bei Anwesenheit von Salz hin. Die Ergebnisse wurden hinsichtlich der Verwendung des Gallensalzes als vielversprechender Wirkstoffträger für den Wirkstoff CPZ und der Verbesserung seiner Bioverfügbarkeit diskutiert.

Correspondence address, Dr. Naved Azum, Center of Excellence for Advanced Materials Research, Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia, E-Mail:

Dr. Naved Azum is an assistant professor at chemistry department, faculty of science, king abdulaziz university, Saudi Arabia. He received his Ph.-D. degree from Aligarh Muslim University, Aligarh, India. He joined University Polytechnic, Zakir Hussain Engineering College, Aligarh Muslim University, as a Lecturer. Currently he is working as an Assistant Professor in the Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He is doing research in biophysical chemistry.

Dr. Malik Abdul Rub received his M.-Sc. and Ph.-D. degree from Aligarh Muslim University, Aligarh, India. Now he has joined King Abdulaziz University as a Assistant Professor in the CEAMR, Faculty of Science. His current research interests are mixed micellization study of amphiphilic drugs with different additives and clouding phenomenon in amphiphilic systems.

Prof. Abdullah M. Asiri is a Professor in Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He received his Ph.-D. degree from Walls College of Cardiff, U.K. He has author more than 500 research papers. His current research interests are smart molecules and materials, novel photochromic and thermodynamic systems, organic synthesis of heterocyclic compounds, synthesis of polymers functionalized with organic dyes and nano hybrid materials.


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Received: 2019-03-11
Accepted: 2019-09-11
Published Online: 2020-06-18
Published in Print: 2020-05-15

© 2020, Carl Hanser Publisher, Munich

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