Abstract
Herein, we investigated the micelle formation of mixed systems of the antipsychotic drug, chlorpromazine hydrochloride (CPZ), and the bile salt, sodium deoxycholate (NaDC), both in the absence and presence of NaCl by tensiometry. To understand the aggregation behaviour of the mixture of these two amphiphiles, we calculated various micellar and interfacial parameters using the theories of Clint, Rubingh, Rosen and Motomura. The calculated interaction parameters indicate an attractive interaction between the two amphiphiles both in the absence and presence of salt. The results were discussed with regard to the use of bile salt as a promising drug carrier for CPZ and the improvement of its bioavailability.
Kurzfassung
Wir untersuchten die Mizellenbildung von Mischsystemen aus dem antipsychotischem Arzneiwirkstoff Chlorpromazinhydrochlorid (Chlorpromazin, CPZ) und dem Gallensalz Natriumdesoxycholat (NaDC) sowohl in Abwesenheit als auch in Anwesenheit von NaCl mittels Tensiometrie. Um das Aggregationsverhalten der Mischung aus diesen beiden Amphiphilen zu verstehen, berechneten wir verschiedene mizellare und grenzflächenbezogene Parameter unter Verwendung der Theorien von Clint, Rubingh, Rosen und Motomura. Die berechneten Wechselwirkungsparameter weisen auf eine attraktive Wechselwirkung zwischen den zwei Amphiphilen sowohl bei Abwesenheit als auch bei Anwesenheit von Salz hin. Die Ergebnisse wurden hinsichtlich der Verwendung des Gallensalzes als vielversprechender Wirkstoffträger für den Wirkstoff CPZ und der Verbesserung seiner Bioverfügbarkeit diskutiert.
References
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