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Synthesis and evaluation of a collagen–brushite cement as a drug delivery system

Paper presented at the “VII International Congress of Biomaterials, BIOMAT'2018”, 14–16 March 2018, Havana, Cuba

  • Claudia Morilla , Yailene M. Lima , Gastón Fuentes and Amisel Almirall


Calcium phosphate cements are known for their biocompatibility and bioactivity, which has led to a significant increase in their use. They have the advantage of being prepared as a malleable paste that sets in a few minutes and can be easily applied in bone defects. In this research work, 6 brushite cement formulations were prepared and the effect of collagen addition and the release of tetracycline were evaluated. All cements gave a malleable paste that set in 2 or 3 min, resulting in a material with pores of 5–20 μm. The cements showed compression resistance values between 0.8 and 1.7 MPa, and the addition of collagen was the most influential factor in the increase of this property. Up to 40 % of the drug was released after 7 days and the effectiveness of its antimicrobial activity was confirmed.

Correspondence address, Dra. Amisel Almirall La Serna, Centro de Biomateriales, Universidad de La Habana, Avenida Universidad e/G y Ronda, Vedado, Plaza, La Habana 10400, Cuba, Tel: +53 7878 0687, e-mail: , Web:


[1] S.V.Dorozhkin: Materials6 (2013) 3840. PMid:28788309; 10.3390/ma6093840Search in Google Scholar

[2] S.V.Dorozhkin: J. Funct. Biomater4 (2013) 209. PMid:24956191; 10.3390/jfb4040209Search in Google Scholar

[3] J.Zhang, W.Liu, V.Schnitzler, F.Tancret, J.-M.Bouler: Acta Biomater10 (2014) 1035. 10.1016/j.actbio.2013.11.001Search in Google Scholar

[4] F.Tamimi, Z.Sheikh, J.Barralet: Acta Biomater8. (2012) 474. PMid:21856456; 10.1016/j.actbio.2011.08.005Search in Google Scholar

[5] Z.Sheikh: Materials8 (2015) 7913. PMid:28793687; 10.3390/ma8115430Search in Google Scholar

[6] C.-L.Ko, J.-C.Chen, C.-C.Hung, J.-C.Wang, Y.-C.Tien, W.-C.Chen: Mater Sci Eng C39 (2014) 40. PMid:24863195; 10.1016/j.msec.2014.02.033Search in Google Scholar

[7] D.L.Alge, W.S.Goebel, T.-M.Gabriel Chu: J. Biomed. Mater. Res. Part B100 (2012) 595. PMid:22323239; 10.1002/jbm.b.31938Search in Google Scholar

[8] M.P.Ginebra, C.Canal, M.Espanol, D.Pastorino, E.B.Montufar: Adv. Drug Deliver. Rev.64 (2012) 1090. PMid:22310160; 10.1016/j.addr.2012.01.008Search in Google Scholar

[9] E.Vorndran, M.Geffers, A.Ewald, M.Lemm, B.Nies, U.Gbureck: Acta Biomater.9 (2013) 9558. PMid:23954526; 10.1016/j.actbio.2013.08.009Search in Google Scholar

[10] A.A.Mirtchi, J.Lemaitre, N.Terao: Biomaterials10 (1989) 475. 10.1016/0142-9612(89)90089-6Search in Google Scholar

[11] R.O’Neill, H.McCarthy, E.Montufar, M.-P.Ginebra, D.Wilson, A.Lennon, N.Dunne: Acta Biomater. (2016) 3. 10.1016/j.actbio.2016.11.019Search in Google Scholar

[12] J.Engstrandn, C.Persson, H.Engqvist: J. Mech. Behav. Biomed. Mater.29 (2014) 81. PMid:24064324; 10.1016/j.jmbbm.2013.08.024Search in Google Scholar

[13] R.M.O’Hara, J.F.Orr, F.J.Buchanan, R.K.Wilcox, D.C.Barton, N.J.Dunne: Acta Biomater.8 (2012) 4043. PMid:22800604; 10.1016/j.actbio.2012.07.003Search in Google Scholar

[14] Y.J.Hong, J.-S.Chun, W.-K.Lee: Colloid Surf. B83 (2011) 245. PMid:21177080; 10.1016/j.colsurfb.2010.11.028Search in Google Scholar

[15] M.C.Bottino, E.A.Münchow, M.T.P.Albuquerque, K.Kamocki, R.Shahi, R.L.Gregory, T.-M.G.Chu, D.Pankajakshan: Biomed. Mater. Res. B.105 (2017) 2085. PMid:27405272; 10.1002/jbm.b.33743Search in Google Scholar

[16] R.G.Shahi, M.T.P.Albuquerque, E.A.Münchow, S.B.Blanchard, R.L.Gregory, M.C.Bottino: Odontology105 (2017) 354. PMid:27585669; 10.1007/s10266-016-0268-zSearch in Google Scholar

[17] R.García Carrodeguas, L.Morejón Alonso, J.A.D.García-Menocal, L.Morejón Alonso, M.P.Ginebra Molins, S.Martínez Manent, J. GilMur, J.Toledo Pérez, J.A.Planell Estany: Mater. Res.6 (2003) 395. 10.1590/S1516-14392003000300014Search in Google Scholar

[18] N.A.Peppas, B.Narasimhan: Controlled Release190 (2014) 75. PMid:24998939; 10.1016/j.jconrel.2014.06.041Search in Google Scholar

[19] A.A.Mirtchi, J.Lemaître, E.Hunting: Biomaterials10 (1989) 634. 10.1016/0142-9612(89)90120-8Search in Google Scholar

[20] J.E.Barralet, L.M.Grover, U.Gbureck: Biomaterials25 (2004) 2197. PMid:14741635; 10.1016/j.biomaterials.2003.09.085Search in Google Scholar PubMed

[21] A. CuneytTas, S.B.Bhaduri. Preparation of Brushite Powders and their in Vitro Conversion to Nanoapatites. In Bioceramics: Materials and Applications V. John Wiley & Sons (2012).Search in Google Scholar

[22] F.J.Richards: J. Exp. Bot.10 (1959) 290. 10.1093/jxb/10.2.290Search in Google Scholar

[23] E.Adams: Int. J. Pharmaceut.240 (2002) 37. 10.1016/S0378-5173(02)00127-8Search in Google Scholar

[24] E.Vallés, D.Durando, I.Katime, E.Mendizábal, J.E.Puig: Polym. Bull.44 (2000) 109. 10.1007/s002890050580Search in Google Scholar

Received: 2018-05-30
Accepted: 2018-10-26
Published Online: 2019-04-03
Published in Print: 2018-04-12

© 2019, Carl Hanser Verlag, München

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