Accessible Requires Authentication Published by De Gruyter May 17, 2019

Synthesis and study of structural, morphological, optical and toxicological properties of ferromagnetic cobalt oxide nanoparticles in liver carcinoma cell line

Paper presented at the “2nd International Conference on Materials Science and Nanotechnology 2018, MSNANO-18”, 22–23 February 2018, Faisalabad, Pakistan

Seemab Iqbal, Muhammad Fakhar-e-Alam, N. Amin, M. Ismail, G. Mustafa, M. Raza Ahmad and M. Atif

Abstract

Cobalt-based nanoparticles are promising candidates towards countless biomedical applications due to their unique characteristics. Co3O4 nanoparticles were synthesized by applying the sol-gel technique and finally sintered at various temperatures (700, 800, 900 °C). The crystal size, morphology, purity, and optical properties were determined using a variety of advanced characterization techniques. To investigate photodynamic therapy feasibility by using Co3O4 nanoparticles in the liver cells, in-vitro cancerous liver cells (HepG2 cells) were exposed to light of wavelength 655 nm (red light) for 30 min at 50 mW cm−2 and in dark as well. After assessment of cell viability analysis, it is concluded that light-induced photodynamic therapy shows significant phototoxic effects based on temperature dependency.


Correspondence address, Dr. Muhammad Atif, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia, E-mail:
∗∗ Dr Muhammad Fakhar-E-Alam, Department of Physics, Govt. College, University, Faisalabad, 38000, Punjab, Pakistan, Tel: +92 331416531, E-mail:

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Received: 2018-04-24
Accepted: 2018-11-10
Published Online: 2019-05-17
Published in Print: 2019-05-15

© 2019, Carl Hanser Verlag, München