Accessible Requires Authentication Published by De Gruyter January 31, 2020

Preparation of salt microparticles via the anti-solvent recrystallization process

Wei Huang, Shuai Pan, Yanghua Liu, Qingmei Yu and Ruijiang Liu


The anti-solvent recrystallization process for the preparation of salt microparticles is introduced. The micron size of salt particles was confirmed by scanning electron microscopy. The preparation conditions such as the antisolvent types, dripping acceleration, stirring time, the volume ratio of antisolvent and solvent, and adding sequence of solvent were optimized. The experimental results indicated that these preparation conditions were as follows: The saturated salt solution was added into absolute alcohol at a dripping acceleration of 10 mL · min−1, a stirring time duration of 30 min, and an antisolvent and solvent volume ratio of 4 : 1. Salt microparticles with an average diameter of about 6.3 μm, uniform size distribution and better crystallization were obtained under the above optimization conditions.

Correspondence address, Prof. Ruijiang Liu, Jiangsu University, School of Pharmacy, Zhenjiang 212013, P.R. China. Fax: +86-511-85038201, E-mail:


[1] P.J. Landrigan , R.Fuller, S.Fisher, W.A.Suk, P.Sly, T.C.Chiles, S.Bose-O'Reilly: Sci. Total Environ.650 (2019) 2389. PMid:30292994; 10.1016/j.scitotenv.2018.09.375 Search in Google Scholar

[2] J. Idavain , K.Julge, T.Rebane, A.Lang, H.Orru: Sci. Total Environ.650 (2019) 65. PMid:30195132; 10.1016/j.scitotenv.2018.08.391 Search in Google Scholar

[3] R.H. Alrashoudi , I.J.Crane, H.M.Wilson, M.Al-Alwan, N.M.Alajez: Bioscience Rep.38 (2018) 1. PMid:30038057; 10.1042/BSR20180548 Search in Google Scholar

[4] W.J. Chen , J.M.Fitzgerald, L.D.Lynd, D.D.Sin, M.Sadatsafavi: J. Aller. Cl. Imm-Pract.6 (2018) 20. 10.1016/j.jaip.2018.04.027 Search in Google Scholar

[5] B.J. Kirenga , C.D.Jong, L.Mugenyi, W.Katagira, A.Muhofa, M.R.Kamya, H.M.Boezen, T.van der Molen: Thorax73 (2018) 983. PMid:29752346; 10.1136/thoraxjnl-2018-211718 Search in Google Scholar

[6] R. Beasley , N.Pearce, J.Crane, C.Burgess: J. Allergy Clin. Immun.104 (1999) 18. 10.1016/s0091-6749(99) Search in Google Scholar

[7] S. Ebmeier , D.Thayabaran, I.Braithwaite, C.Bénamara, M.Weatherall, R.Beasley: Lancet390 (2017) 935. 10.1016/S0140-6736(17)31448-4 Search in Google Scholar

[8] C.F. Rider , C.Carlsten: Pharmacol. Therapeut.194 (2019) 1. PMid:30138638; 10.1016/j.pharmthera.2018.08.005 Search in Google Scholar

[9] M.M. Mostafa , C.F.Rider, S.Shah, S.L.Traves, P.M.K.Gordon, A.Miller-Larsson, R.Leigh, R.Newton: BMC. Med. Genomics12 (2019) 1. PMid:30704470; 10.1186/s12920-018-0467-2 Search in Google Scholar

[10] E. Laszlo : Orvosi Hetilap156 (2015) 1643. PMid:26551167; 10.1556/650.2015.30267 Search in Google Scholar

[11] N. Luminita , C.G.Cirstoveanu, A.I.Istrate-Barzan, B.Il-Eana, S.Manolache, M.Bizubac, A.Gaiduchevici: Signa Vitae13 (2017) 85. 10.22514/SV132.112017.13 Search in Google Scholar

[12] P.G. Durham , Y.Zhang, N.German, N.Mortensen, J.Dhillon, D.A.Mitchison, P.B.Fourie, A.J.Hickey: Mol. Pharm.12 (2015) 2574. PMid:26098136; 10.1021/acs.molpharmaceut.5b00118 Search in Google Scholar

[13] L.D. Castillo-Peinado , Castro: J. Pharm. Pharmacol.68 (2016) 1249. PMid:27464836; 10.1111/jphp.12614 Search in Google Scholar

[14] R. Rashleigh , S.M.S.Smith, N.J.Roberts: Int. J. Chronic Obstr.9 (2014) 239. 10.2147/COPD.S57511 Search in Google Scholar

[15] E. Laszlo : Orvosi Hetilap157 (2016) 1019. PMid:27319382; 10.1556/650.2016.30449 Search in Google Scholar

[16] Y. Wada , M.Matsumoto, K.Onoe: J. Cryst. Growth373 (2013) 92. 10.1016/j.jcrysgro.2012.11.061 Search in Google Scholar

[17] D. Gao , M.Jia: Appl. Surf. Sci.35 (2015) 89. 10.1016/j.apsusc.2015.09.235 Search in Google Scholar

[18] L.L. Liu , F.Gao, Y.M.Zhang: J. Mater. Sci-Mater. El.26 (2015) 1136. 10.1007/s10854-014-2517-7 Search in Google Scholar

[19] T.G. Zijlema , R.M.Geertman, G.J.Witkamp, G.M.van Rosmalen, Graauw: Ind. Eng. Chem. Res.39 (2000) 1330. 10.1021/ie990221h Search in Google Scholar

[20] Y. Wada , M.Matsumoto, K.Onoe: J. Cryst. Growth448 (2016) 76. 10.1016/j.jcrysgro.2016.03.043 Search in Google Scholar

[21] S. Sawamura , N.Egoshi, Y.Setoguchi, H.Matsuo: Fluid Phase Equilibr.254 (2007) 158. 10.1016/j.fluid.2007.03.003 Search in Google Scholar

[22] M. Barrett , D.O'Grady, E.Casey, B.Glennon: Chem. Eng. Sci.66 (2011) 2523. 10.1016/j.ces.2011.02.042 Search in Google Scholar

[23] L. Padrela , J.Zeglinski, K.M.Ryan: Cryst. Growth Des.17 (2017) 4544. 10.1021/acs.cgd.7b00163 Search in Google Scholar

[24] J. Lee , M.Ashokkumar, S.E.Kentish: Ultrason. Sonochem.21 (2014) 60. 10.1016/j.ultsonch.2013.07.005 Search in Google Scholar

[25] R. Phillips , S.Rohani, J.Baldyga: Aiche J.45 (1999) 82. 10.1002/aic.690450108 Search in Google Scholar

[26] A. Tulcidas , S.Nascimento, B.Santos, C.Alvarez, S.Pawlowski, F.Rocha: Sep. Purif. Technol.213 (2019) 56. 10.1016/j.seppur.2018.12.019 Search in Google Scholar

[27] E.R. Townsend , W.J.P.van Enckevort, P.Tinnemans, M.A.R.Blijlevens, J.A.M.Meijer, E.Vlieg: Cryst. Growth Des.18 (2018) 755. PMid:29910693; 10.1021/acs.cgd.7b01170 Search in Google Scholar

Received: 2019-04-15
Accepted: 2019-08-13
Published Online: 2020-01-31
Published in Print: 2020-02-12

© 2020, Carl Hanser Verlag, München