Abstract
A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee).
Graphical Abstract
Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions
Received: 2012-08-21
Published Online: 2014-06-02
Published in Print: 2013-01-01
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
