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Licensed Unlicensed Requires Authentication Published by De Gruyter June 2, 2014

Antileishmanial Compounds from Moringa oleifera Lam.

  • Amandeep Kaur , Preet Kamal Kaur , Sushma Singh and Inder Pal Singh EMAIL logo

The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam: was investigated in vitro against promastigotes of Leishmania donavani. The 70%ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of 83:0 μg/ml and 47:5 μg/ml, respectively. Antileishmanial activity of the methanolic extract of leaves increased upon fractionation, as its ethyl acetate fraction was found to be more active with an IC50 value of 27:5 mg=ml. The most active antileishmanial compound niazinin, a thiocarbamate glycoside isolated from this fraction, showed an IC50 value of 5:25 mM. Results presented in this study indicate that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.

Received: 2013-9-22
Revised: 2013-11-8
Published Online: 2014-6-2
Published in Print: 2014-4-1

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