Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 19, 2015

Antihyperglycemic Activities of Extracts of the Mistletoes Plicosepalus acaciae and P. curviflorus in Comparison to their Solid Lipid Nanoparticle Suspension Formulations

Hibah M. Aldawsari , Abeer Hanafy EMAIL logo , Gihan S. Labib and Jihan M. Badr


The antihyperglycemic activity of the extracts and preparations of solid lipid nanoparticle suspensions of two mistletoes growing in Saudi Arabia, Plicosepalus acaciae and P. curviflorus, as well as their possible antioxidant effect were investigated in a type 2 diabetic animal model. Type 2 diabetes was induced in adult maleWistar rats by a high-fat diet followed by injection of streptozotocin (STZ). The diabetic rats were treated in parallel with pioglitazone hydrochloride (PIO), non-toxic extracts of P. acaciae and P. curviflorus, as well as three different solid lipid nanoparticle (SLN) suspension formulations prepared from each of the two extracts. Blood glucose level, insulin resistance, oxidative stress parameters, and antioxidant markers were determined. The total extracts of P. acaciae and P. curviflorus as well as the SLN formulations exhibited a significant blood glucose-lowering effect associated with antioxidant effects in the diabetic rats. The SLN preparation with the highest lipid content gave the best result. Reduction of hyperglycemia and insulin resistance in the diabetic rats was, at least partly, due to the antioxidant activities of the extracts and their SLN formulations.

Received: 2014-3-4
Accepted: 2014-7-10
Published Online: 2015-3-19
Published in Print: 2014-10-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

Downloaded on 29.11.2022 from
Scroll Up Arrow