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Licensed Unlicensed Requires Authentication Published by De Gruyter March 19, 2015

Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa

Muhamad S. Fareza , Yana M. Syah EMAIL logo , Didin Mujahidin , Lia D. Juliawaty and Iis Kurniasih


Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1 - 4), from the acetone extract of the leaves of Macaranga trichocarpa. Reexamination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 μM achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.

Received: 2014-3-27
Accepted: 2014-10-2
Published Online: 2015-3-19
Published in Print: 2014-10-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

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