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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access September 17, 2014

The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

  • Naim Ata , Kürşat Dal , Metin Kucukazman , Abdullah Ö. Yeniova EMAIL logo , Serdar Karakaya , Oktay Unsal , Murat Dagdeviren , Kadir O. Akın , Salih Baser , Esin Beyan and Derun T. Ertugrul
From the journal Open Medicine

Abstract

Background: Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.

Methods: A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.

Results: Fasting blood glucose, HbA1c, CA19-9,CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylaseand lipase.

Conclusions: We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.

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Received: 2014-3-30
Accepted: 2014-7-29
Published Online: 2014-9-17

© 2015 Naim Ata, et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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