Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter April 24, 2015

Steroids in critically ill-patients with septic shock and acute respiratory distress syndrome: A limited review of current knowledge

  • Jouke De Regt EMAIL logo

Abstract

The role of corticosteroids in critically ill patients has always been discussed by researchers and clinicians dedicated in the related field. Despite several decades of clinical studies exploring their role in both sepsis and treatment of acute respiratory distress syndrome (ARDS), their use remains controversial. This short review highlights current knowledge and opinions.

References

1. Boonen E, Vervenne H, Meersseman P, Andrew R, Mortier L, Declercq PE, et al. Reduced cortisol metabolism during critical illness. N Engl J Med 2013;368:1477-88.10.1056/NEJMoa1214969Search in Google Scholar PubMed PubMed Central

2. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003;348:727-34.10.1056/NEJMra020529Search in Google Scholar PubMed

3. Marik PE. Critical illness-related corticosteroid insufficiency. Chest 2009;135:181-93.10.1378/chest.08-1149Search in Google Scholar PubMed

4. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008;36:1937-49.10.1097/CCM.0b013e31817603baSearch in Google Scholar PubMed

5. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med 1987;317:659-65.10.1056/NEJM198709103171102Search in Google Scholar PubMed

6. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-71.10.1001/jama.288.7.862Search in Google Scholar PubMed

7. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111-24.10.1056/NEJMoa071366Search in Google Scholar PubMed

8. Annane D, Bellissant E, Bollaert PE, Briegel J, Confalonieri M, De Gaudio R, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults: A systematic review. JAMA 2009;301:2362-75.10.1001/jama.2009.815Search in Google Scholar PubMed

9. Minneci PC, Deans KJ, Eichacker PQ, Natanson C. The effects of steroids during sepsis depend on dose and severity of illness: An updated meta-analysis. Clin Microbiol Infect 2009;15:308-18.10.1111/j.1469-0691.2009.02752.xSearch in Google Scholar PubMed PubMed Central

10. Sligl WI, Milner DA Jr, Sundar S, Mphatswe W, Majumdar SR. Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis. Clin Infect Dis 2009;49:93-101.10.1086/599343Search in Google Scholar PubMed

11. Casserly B, Gerlach H, Phillips GS, Lemeshow S, Marshall JC, Osborn TM, et al. Low-dose steroids in adult septic shock: Results of the Surviving Sepsis Campaign. Intensive Care Med 2012;38:1946-54.10.1007/s00134-012-2720-zSearch in Google Scholar PubMed

12. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165-228.10.1007/s00134-012-2769-8Search in Google Scholar PubMed PubMed Central

13. Sprung CL, Caralis PV, Marcial EH, Pierce M, Gelbard MA, Long WM, et al. The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med 1984;311:1137-43.10.1056/NEJM198411013111801Search in Google Scholar PubMed

14. Bernard GR, Luce JM, Sprung CL, Rinaldo JE, Tate RM, Sibbald WJ, et al. High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 1987;317:1565-70.10.1056/NEJM198712173172504Search in Google Scholar PubMed

15. Meduri GU, Headley AS, Golden E, Carson SJ, Umberger RA, Kelso T, et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: A randomized controlled trial. JAMA 1998;280:159-65.10.1001/jama.280.2.159Search in Google Scholar PubMed

16. Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, et al. Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial 2007. Chest 2009;136:e30.Search in Google Scholar

17. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006;354:1671-84.10.1056/NEJMoa051693Search in Google Scholar PubMed

18. Agarwal R, Nath A, Aggarwal AN, Gupta D. Do glucocorticoids decrease mortality in acute respiratory distress syndrome? A meta-analysis. Respirology 2007;12:585-90.10.1111/j.1440-1843.2007.01060.xSearch in Google Scholar PubMed

19. Peter JV, John P, Graham PL, Moran JL, George IA, Bersten A. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: Meta-analysis. BMJ 2008;336:1006-9.10.1136/bmj.39537.939039.BESearch in Google Scholar PubMed PubMed Central

20. Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen A, et al. Steroid treatment in ARDS: A critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 2008;34:61-9.10.1007/s00134-007-0933-3Search in Google Scholar PubMed

21. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med 2013;369:2126-36. 10.1056/NEJMra1208707Search in Google Scholar PubMed

Published Online: 2015-4-24
Published in Print: 2014-6-1

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 19.3.2024 from https://www.degruyter.com/document/doi/10.4103/2224-4018.135604/html
Scroll to top button