Abstract
A number of 25 nitro-diphenylethers have been synthesized and assayed for their inhibitory activity in N-methylphenazonium-methosulfate mediated cyclic photophosphorylation. Their pI50-values were in the range from 3.5 to 5.3. A QSAR-analysis revealed that the lipophilicity of the nitro-diphenylethers as expressed by ∑π played a major role. In addition, the Taft steric parameter Es in positions 6′, 4′ and 2′ (in decreasing order) contributed to the inhibitory activity. For maximal biological activity, positions 4′ and 6′ should be left unsubstituted whereas a bulky substituent is required for position 2′.
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.