Human granulocytes exposed to pulsed electric guiding fields were investigated. The trajectories were determined from digitized pictures (phase contrast). The basic results are: (i) No directed response was induced by pulsed electric guiding fields having a zero averaged field, (ii) A directed response was induced by pulsed electric guiding fields having a non-zero averaged field, (iii) The directed response was enhanced for pulse sequencies having a repetition time of 8 s. (iv) The lag-time between signal recognition and cellular response was 8 - 10 s. The results are discussed in the framework of a self-ignition model
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