This study tests for similarities and differences in the uses of near-synonymous mental predicates by speakers of different ENL and ESL speech communities to capture whether, and if so to what degree, speakers of different first and second language English varieties use the four near-synonymous predicates semantically differently. Specifically, we focus on I believe, I think, I suppose and I guess in eight native and second-language varieties of English (i.e. American, British, Canadian, Irish, Hong Kong, Indian, Singapore and New Zealand). We adopt a multivariate modeling approach to analyze mental predicates annotated for six semantic variables (verifiability, epistemic mode, epistemic class, epistemic type, evaluation and negotiability) as well as genre. Our findings show the usefulness of exploring Englishes through the lens of semantic structure. Although, on the surface, two groups of English varieties emerge with different preferential patterns of predicates (British, Indian, Irish and Singapore vs. Canadian, Hong Kong and American), at a more abstract level, those predicates share similar semantic combinatory patterns common to all varieties in focus. It emerges that modeling the development of Englishes based on theoretical frameworks that account for simultaneous development of generic (i.e. common to all Englishes) and specialized (i.e. specific to individual Englishes) linguistic patterns may be beneficial. At a time when English has become a worldwide language shaped by globalization, the present study adds to the discussion on the developmental pathways that characterize the evolution of non-native Englishes in the twenty-first century.