The aliphatic polyesters: polylactides (PLA), polyglycolides (PGA), poly( -caprolactone) (PCL) as well as their copolymers especially, poly(lactide-coglycolide) (PLGA), poly(vinyl alcohol) (PVA), chitosan, dextran and starch occupy first place among biodegradable, biocompatible and non-toxic polymers. PVA, with different molecular weights, hydrolysis degree, tacticity, crystallinity, and due to the abundance of pendant hydroxy groups in the backbone is capable of several grafting and cross-linking. The present study concerns the synthesis of graft copolymers poly(vinyl alcohol) with lactic acid (LA) and aspartic acid (Asp). The modification reaction of poly(vinyl alcohol) with lactic and aspartic acid was achieved by solution polycondensation using dioxane/water (3/1) as solvent mixture, different molar ratios PVA/LA/Asp and manganese acetate as catalyst: Mn(CH 3 COO) 2 4H 2 O. The copolymers were characterized by FTIR, 1 H-NMR, thermal stability (DSC, TG), elemental analysis, wide angle X-ray diffraction (WAXD). The average particle size and zeta potential for aqueous dispersions of copolymers, solubility in organic solvents and biodegradation testing on agar-agar medium inoculated with a fungus Chaetomium globosum class MO5 stock, were studied.