Francisco Estrada-Rojo, Ricardo Jesús Martínez-Tapia, Francisco Estrada-Bernal, Marina Martínez-Vargas, Adán Perez-Arredondo, Luis Flores-Avalos, Luz Navarro
September 9, 2017
Traumatic brain injury (TBI) is a contemporary health problem and a leading cause of mortality and morbidity worldwide. Survivors of TBI frequently experience disabling long-term changes in cognition, sensorimotor function, and personality. A crucial step in understanding TBI and providing better treatment has been the use of models to mimic the event under controlled conditions. Here, we describe the known head injury models, which can be classified as whole animal ( in vivo ), in vitro , and mathematical models. We will also review the ways in which these models have advanced the knowledge of TBI.