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Volume 15 Issue 1-2 - Special Issue: Medical Textiles / Editor: Stefan Jockenhoevel

Issue of BioNanoMaterials

Contents
Journal Overview

Publicly Available October 8, 2014

Editorial

October 8, 2014

Special Issue: Medical Textiles

Stefan Jockenhoevel

Page range: 1-1

Highlights

September 20, 2014

MR-visualization of surgical textile implants

Jens Otto, Nicolas Kuehnert, Daniel Busch, Andreas Lambertz, Christian Klink, Nienke L. Hansen, Alexander Ciritsis, Christiane Kuhl, Uwe Klinge, Ulf Peter Neumann, Joachim Conze, Nils A. Kraemer

Page range: 3-8

Abstract

The use of surgical textile implants (so-called “mesh”) for hernia repair is an accepted standard. They may cause mesh-related problems such as chronic pain, migration or fistula formation. Nevertheless, these polymer-based textile meshes are often invisible by conventional imaging methods like computed tomography (CT) and magnetic resonance imaging (MRI). In this study we outlined the major steps in the development of a MR-visible textile implant, which can be used in patients. To achieve MR-visability, ferrooxide particles were incorporated into the base material polyvinylidene fluoride (PVDF), during the spinning process. We could proof the MR-visibility of this new textile implant in different phantoms. After clinical approval of these implants in vivo in different animal studies, we pursued to evaluate the MR-conspicuity of such ferrooxide-loaded mesh implants in patients treated for inguinal hernias and explored the postsurgical mesh configuration by MRI. In this study we described the development and first results of a ferrooxide-loaded MR-visible mesh. In animal model and in clinical use such implants turned out to be a valuable tool for diagnostic and development.

August 5, 2014

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

Loredana Tammaro, Vittoria Vittoria, Ralf Wyrwa, Jürgen Weisser, Birgitt Beer, Susanne Thein, Matthias Schnabelrauch

Page range: 9-20

Abstract

Non-woven hybrid meshes based on poly( l -lactide- co - d,l -lactide) ( dl -PLA) and β-tricalcium phosphate (β-TCP) were fabricated and comprehensively characterized. Stock suspensions of β-TCP powder in dl -PLA acetone solutions were used for the electrospinning process. Structure, morphology and thermal properties of the electrospun samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The electrospun hybrid materials show a micro-composite structure, and a morphology characterized by a three-dimensional porous fibrous mesh with randomly distributed fibers possessing average fiber diameters between 680 and 970 nm, uniform thickness along the fibers and beads structure only for higher β-TCP concentration electrospun samples. Both pure PLA and hybrid non-woven meshes exhibit a good thermal stability and a continuous degradation in simulated body fluid medium. A live/dead staining viability assay using MC3T3-E1 preosteoblasts reveals the excellent cytocompatibility of the fabricated non-wovens. Enhanced alkaline phosphatase (AP) activity of MC3T3-E1 cells during culture on the dl -PLA and the composite non-woven meshes demonstrates their potential for applications in hard tissue repair.

October 8, 2014

Elastic filaments from thermoplastic polyurethanes for application in highly elastic mesh implants

Philipp Schuster, Klas-Moritz Kossel, Andreas Lambertz, Ruben Raoul Marginus Vogels, Christian Daniel Klink, Uwe Klinge, Thomas Gries, Stefan Jockenhoevel

Page range: 21-24

Abstract

One goal for the development of novel mesh implants is the adaption of the implant’s mechanical properties to the physiological properties of the native tissue. Following this approach there is a multitude of interesting applications where implant structures with a defined elastic behaviour are required. Textile structures made out of elastic filaments can fulfil these requirements. In this study, we investigated the melt spinning process for medical grade poly(carbonat)urethanes (PCU) aiming at fibres with an appropriate elasticity for the usage in elastic mesh implants. Filaments with good elastic properties and high recovery rates could be produced out of PCU with shore 93A.

August 5, 2014

Stresses produced by different textile mesh implants in a tissue equivalent

Ralf Frotscher, Manfred Staat

Page range: 25-30

Abstract

Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.

October 8, 2014

Antibacterial polyamides based on a dendritic zinc-hybrid with good biocompatibility showing reduced biofilm formation

Michael Gladitz, Janine Bauer, Peggy Brückner, Stefan Reinemann, Cornelia Wiegand, Michael Zieger, Kirsten Reddersen, Uta-Christina Hipler, Marion Frant, Klaus Liefeith, Hans-Joachim Radusch

Page range: 31-46

Abstract

Antimicrobial organic-inorganic hybrids based on amphiphilic dendritic hyperbranched polyethylenimine with zinc were prepared. To study their property profile and potential as an antimicrobial modifier they were incorporated via melt extrusion into cast films or injection molded into plates of polyamide (PA). The antimicrobial efficacy, bacterial adhesion, cytotoxicity and blood compatibility of the respective PA composites were investigated as a function of material composition and morphology. It could be demonstrated that the polymers with the developed zinc-hybrids possess a high antimicrobial efficacy as well as good cyto- and hemo-compatibility in vitro. Furthermore, they showed reduced bacterial adhesion. Finally, it can be stated that the developed zinc-hybrids are suitable as advanced additive agents for the production of antimicrobial polymer materials with promising properties particular for various medical applications.

About this journal

This journal has ceased publication.

Volume 15 Issue 1-2 - Special Issue: Medical Textiles / Editor: Stefan Jockenhoevel

Issue of BioNanoMaterials

Frontmatter

Special Issue: Medical Textiles

MR-visualization of surgical textile implants

Abstract

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

Abstract

Elastic filaments from thermoplastic polyurethanes for application in highly elastic mesh implants

Abstract

Stresses produced by different textile mesh implants in a tissue equivalent

Abstract

Antibacterial polyamides based on a dendritic zinc-hybrid with good biocompatibility showing reduced biofilm formation

Abstract