Published since January 1, 1956

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

ISSN: 1862-278X

Editor-in-chief: Jens Haueisen

Edited by: Peter Augat, Thomas M. Deserno, Steffen Leonhardt, Gernot Plank, Klaus M. Radermacher, Erik Schkommodau, Thomas Stieglitz

Impact Factor: 1.426

About this journal

Objective
Biomedical Engineering / Biomedizinische Technik (BMT) is a high-quality forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering. As an established journal with a tradition of more than 60 years, BMT addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice. All articles are peer-reviewed. All manuscripts must be submitted in English.

Topics

diagnostic imaging
image processing
biosignal processing
modelling and simulation
biomechanics
information and communication in medicine
telemedicine and e-health
surgery
minimum invasive interventions
endoscopy and image-guided therapy
diagnostic and therapeutic instrumentation
clinical engineering
micro- and nanosystems in medicine
active implants
biosensors
neuro-engineering
neural systems
rehabilitation and prosthetics
biomaterials
cellular and tissue engineering
artificial organs
biomedical engineering for audiology, ophthalmology, emergency and dental medicine
general subjects (e.g., education and training, health technology assessment)
special topics (e.g., linking proteomics and genomics with biomedical engineering, emergency medicine)

Article formats
Reviews, Research Articles, Short Communications

Your Benefits

Your benefits:

Imperative topic
Applicative approach to engineering facilities and methods
New areas of application of cutting-edge technologies in modern medicine
State-of-the-art solutions for requirements in current medical practice
Ahead-of-print online publication

History

The Journal was founded in 1956 as the official journal of the German Society of Biomedical Engineering Biomedizinische Technik and published firstly in German. In a transition period as of 2004 publication in German and English was possible, but since 2010 the journal appears only in English. Consistently the title was changed to Biomedical Engineering – Biomedizinische Technik.

Other publications in the field

Journals:

Books, books series and multi-volume works:

„Biomedizinische Technik” (12 Volumes). (Overview)
S. Dickel, M. Franzen, Ch. Kehl, Herausforderung Biomedizin. Gesellschaftliche Deutung und soziale Praxis, “VerKörperungen/MatteRealities - Perspektiven empirischer Wissenschaftsforschung 14”, 2014.(Overview)
D. Hochmann, Prüf- und Bewertungsmethoden für Knieorthesen, “Forschung für die Rehabilitationstechnik 1”, 2012.(Overview)
K. König, A. Ostendorf (Eds.), Optically Induced Nanostructures. Biomedical and Technical Applications, 2015. (Overview)
W. Niederlag, H. U. Lemke, H. Lehrach, H.-O. Peitgen, Der virtuelle Patient, “Health Academy 1”, 2014.(Overview)
W. Niederlag, H. U. Lemke et al., Der digitale Operationssaal, “Health Academy 2”, 2014.(Overview)
I. Roterman-Konieczna (Ed.), Simulations in Medicine. Pre-Clinical and Clinical Applications, 2015.(Overview)
J. Werner, Kooperative und autonome Systeme der Medizintechnik. Funktionswiederherstellung und Organersatz, 2014.(Overview)

Previous Titles

2012: from Biomedizinische Technik – Biomedical Engineering to Biomedical Engineering – Biomedizinische Technik

Abstracting and Indexing

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Supplementary Materials

Topics

External Links

Volume 67 Issue 6

December 2022

Publicly Available November 28, 2022

Frontmatter

Page range: i-iii

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Reviews

September 14, 2022

Nano-material utilization in stem cells for regenerative medicine

Darin Sawah, Maha Sahloul, Fatih Ciftci

Page range: 429-442

Abstract

The utilization of nanotechnology in regenerative medicine has been globally proven to be the main solution to many issues faced with tissue engineering today, and the theoretical and empirical investigations of the association of nanomaterials with stem cells have made significant progress as well. For their ability to self-renew and differentiate into a variety of cell types, stem cells have become popular candidates for cell treatment in recent years, particularly in cartilage and Ocular regeneration. However, there are still several challenges to overcome before it may be used in a wide range of therapeutic contexts. This review paper provides a review of the various implications of nanomaterials in tissue and cell regeneration, the stem cell and scaffold application in novel treatments, and the basic developments in stem cell-based therapies, as well as the hurdles that must be solved for nanotechnology to be used in its full potential. Due to the increased interest in the continuously developing field of nanotechnology, demonstrating, and pinpointing the most recognized and used applications of nanotechnology in regenerative medicine became imperative to provide students, researchers, etc. who are interested.

September 5, 2022

Active cell capturing for organ-on-a-chip systems: a review

Morteza Bayareh

Page range: 443-459

Abstract

Organ-on-a-chip (OOC) is an emerging technology that has been proposed as a new powerful cell-based tool to imitate the pathophysiological environment of human organs. For most OOC systems, a pivotal step is to culture cells in microfluidic devices. In active cell capturing techniques, external actuators, such as electrokinetic, magnetic, acoustic, and optical forces, or a combination of these forces, can be applied to trap cells after ejecting cell suspension into the microchannel inlet. This review paper distinguishes the characteristics of biomaterials and evaluates microfluidic technology. Besides, various types of OOC and their fabrication techniques are reported and various active cell capture microstructures are analyzed. Furthermore, their constraints, challenges, and future perspectives are provided.

Research Articles

Open Access September 13, 2022

Towards technically controlled bioreactor maturation of tissue-engineered heart valves

Kirsten Voß, Maximilian P. Werner, Jonas Gesenhues, Vytautas Kučikas, Marc van Zandvoort, Stefan Jockenhoevel, Thomas Schmitz-Rode, Dirk Abel

Page range: 461-470

More Download PDF

Abstract

Bioreactors are important tools for the pre-conditioning of tissue-engineered heart valves. The current state of the art mostly provides for timed, physical and biochemical stimulation in the bioreactor systems according to standard protocols (SOP). However, this does not meet to the individual biological variability of living tissue-engineered constructs. To achieve this, it is necessary to implement (i) sensory systems that detect the actual status of the implant and (ii) controllable bioreactor systems that allow patient-individualized pre-conditioning. During the maturation process, a pulsatile transvalvular flow of culture medium is generated within the bioreactor. For the improvement of this conditioning procedure, the relationship between the mechanical and biochemical stimuli and the corresponding tissue response has to be analyzed by performing reproducible and comparable experiments. In this work, a technological framework for maturation experiments of tissue-engineered heart valves in a pulsating bioreactor is introduced. The aim is the development of a bioreactor system that allows for continuous control and documentation of the conditioning process to increase reproducibility and comparability of experiments. This includes hardware components, a communication structure and software including online user communication and supervision. Preliminary experiments were performed with a tissue-engineered heart valve to evaluate the function of the new system. The results of the experiment proof the adequacy of the setup. Consequently, the concept is an important step for further research towards controlled maturation of tissue-engineered heart valves. The integration of molecular and histological sensor systems will be the next important step towards a fully automated, self-controlled preconditioning system.

August 31, 2022

In vitro thrombogenicity evaluation of rotary blood pumps by thromboelastometry

Mario Klein, Jana Christine Tack, Ilona Mager, Judith Maas, Thomas Schmitz-Rode, Jutta Arens, Ulrich Steinseifer, Johanna Charlotte Clauser

Page range: 471-480

Abstract

In vitro thrombogenicity tests for rotary blood pumps (RBPs) could benefit from assessing coagulation kinematics, as RBP design improves. In this feasibility study, we investigated if the method of thromboelastometry (TEM) is able to assess coagulation kinematics under the in vitro conditions of RBP tests. We conducted in vitro thrombogenicity tests (n=4) by placing Deltastream ® DP3 pumps into test loops that were filled with 150 mL of slightly anti-coagulated porcine blood, adjusted to an activated clotting time (ACT) well below clinically recommended levels. Blood samples were taken at certain time points during the experiment until a continuous decrease in pump flow indicated major thrombus formation. Blood samples were analyzed for ACT, platelet count (PLT), and several TEM parameters. While visible thrombus formation was observed in three pumps, ACT indicated an ongoing activation of coagulation, PLT might have indicated platelet consumption. Unexpectedly, most TEM results gave no clear indications. Nonetheless, TEM clotting time obtained by non-anticoagulated and chemically non-activated whole blood (HEPNATEM-CT) appeared to be more sensitive for the activation of coagulation in vitro than ACT, which might be of interest for future pump tests. However, more research regarding standardization of thrombogenicity pump tests is urgently required.

August 19, 2022

Effects of weight gaining to lower limb joint moments: a gender-specific sit-to-stand analysis

Kasim Serbest

Page range: 481-489

Abstract

The prevalence of obesity, a worldwide health problem, is increasing. Obesity or overweight has significant effects, especially on lower limb biomechanics. Previous studies have investigated the biomechanical effects of weight gain on the knee and hip joints. These studies have been conducted on different individuals with normal weight and overweight. However, no investigation has been carried out between women and men in terms of weight gain. Females usually gain weight in the gluteal-femoral region, whereas males gain weight in the abdominal region. Due to this difference, it is thought that the effects of weight gain should be examined in a gender-specific manner. In this study, a link-segment model of the lower limb was created. Then the sit-to-stand movement was simulated according to female and male-specific weight gain scenarios. According to these results, weight gain in the abdominal region (men-specific) increases the ankle and knee joint moments more than weight gain in the gluteal-femoral region (women-specific). In obese scenarios for males and females, while the ankle and knee joint moment increases, the hip joint moment decreases. These results would be beneficial for considering biomechanical differences caused by gender-specific weight gain in rehabilitation processes and orthotic and prosthetic designs.

September 12, 2022

Evaluation method of ex vivo porcine liver reduced scattering coefficient during microwave ablation based on temperature

Xiaofei Jin, Wenwen Liu, Yiran Li, Lu Qian, Qiaoqiao Zhu, Weitao Li, Zhiyu Qian

Page range: 491-501

Abstract

The principle of microwave ablation (MWA) is to cause irreversible damage (protein coagulation, necrosis, etc.) to tumor cells at a certain temperature by heating, thereby destroying the tumor. We have long used functional near-infrared spectroscopy (fNIRs) to monitor clinical thermal ablation efficacy. After a lot of experimental verification, it can be found that there is a clear correlation between the reduced scattering coefficient and the degree of tissue damage. During the MWA process, the reduced scattering coefficient has a stable change. Therefore, both temperature (T) and reduced scattering coefficient ( μ s ′ ${\mu }_{s}^{\prime }$ ) are related to the thermal damage of the tissue. This paper mainly studies the changing law of T and μ s ′ ${\mu }_{s}^{\prime }$ during MWA and establishes a relationship model. The two-parameter simultaneous acquisition system was designed and used to obtain the T and μ s ′ ${\mu }_{s}^{\prime }$ of the ex vivo porcine liver during MWA. The correlation model between T and μ s ′ ${\mu }_{s}^{\prime }$ is established, enabling the quantitative estimation of μ s ′ ${\mu }_{s}^{\prime }$ of porcine liver based on T. The maximum and the minimum relative errors of μ s ′ ${\mu }_{s}^{\prime }$ are 79.01 and 0.39%, respectively. Through the electromagnetic simulation of the temperature field during MWA, 2D and 3D fields of reduced scattering coefficient can also be obtained using this correlation model. This study contributes to realize the preoperative simulation of the optical parameter field of microwave ablation and provide 2D/3D therapeutic effect for clinic.

September 14, 2022

Optical bone densitometry insensitive to skin thickness

Kaname Miura, Anak Khantachawana, Tsuyoshi Wakamori, Hidenori Matsubara, Shigeo M. Tanaka

Page range: 503-512

Abstract

Skin thickness, including the adipose layer, which varies from individual to individual, affects the bone density measurement using light. In this study, we proposed a method to measure skin thickness using light and to correct the bias caused by differences in skin thickness and verified the proposed method by experiments using a phantom. We measured simulated skin of different thicknesses and bovine trabecular bone of different bone mineral densities (BMDs) using an optical system consisting of lasers of 850 and 515 nm wavelengths, lenses, and slits. Although the slope of the light intensity distribution formed on the surface of the material when irradiated by the 850 nm laser is affected by the thickness of the skin phantom. The difference of the intensity distribution peaks (δ y ) between the 850 and 515 nm lasers was strongly correlated with the thickness of the skin phantom. The coefficient of determination between the measurements and the BMD was improved by correcting the 850 nm laser measurements with δ y . This result suggests that the method is applicable to optical bone densitometry, which is insensitive to differences in skin thickness.

September 26, 2022

Computer aided detection of tuberculosis using two classifiers

Abdullahi Umar Ibrahim, Fadi Al-Turjman, Mehmet Ozsoz, Sertan Serte

Page range: 513-524

Abstract

Abstracts Tuberculosis caused by Mycobacterium tuberculosis have been a major challenge for medical and healthcare sectors in many underdeveloped countries with limited diagnosis tools. Tuberculosis can be detected from microscopic slides and chest X-ray but as a result of the high cases of tuberculosis, this method can be tedious for both microbiologist and Radiologist and can lead to miss-diagnosis. The main objective of this study is to addressed these challenges by employing Computer Aided Detection (CAD) using Artificial Intelligence-driven models which learn features based on convolution and result in an output with high accuracy. In this paper, we described automated discrimination of X-ray and microscopic slide images of tuberculosis into positive and negative cases using pretrained AlexNet Models. The study employed Chest X-ray dataset made available on Kaggle repository and microscopic slide images from both Near East university hospital and Kaggle repository. For classification of tuberculosis and healthy microscopic slide using AlexNet+Softmax, the model achieved accuracy of 98.14%. For classification of tuberculosis and healthy microscopic slide using AlexNet+SVM, the model achieved 98.73% accuracy. For classification of tuberculosis and healthy chest X-ray images using AlexNet+Softmax, the model achieved accuracy of 98.19%. For classification of tuberculosis and healthy chest X-ray images using AlexNet+SVM, the model achieved 98.38% accuracy. The result obtained has shown to outperformed several studies in the current literature. Future studies will attempt to integrate Internet of Medical Things (IoMT) for the design of IoMT/AI-enabled platform for detection of Tuberculosis from both X-ray and Microscopic slide images.

Ahead of Print / Just Accepted

Ahead of Print / Just Accepted

Volume 67 (2022)

Volume 66 (2021)

Volume 65 (2020)

Volume 64 (2019)

Volume 63 (2018)

Volume 62 (2017)

Volume 61 (2016)

Volume 60 (2015)

Volume 59 (2014)

Volume 58 (2013)

Volume 57 (2012)

Volume 56 (2011)

Volume 55 (2010)

Volume 54 (2009)

Volume 53 (2008)

Volume 52 (2007)

Volume 51 (2006)

Volume 50 (2005)

Volume 49 (2004)

Volume 48 (2003)

Volume 47 (2002)

Volume 46 (2001)

Volume 45 (2000)

Volume 44 (1999)

Volume 43 (1998)

Volume 42 (1997)

Volume 41 (1996)

Volume 40 (1995)

Volume 39 (1994)

Volume 38 (1993)

Volume 37 (1992)

Volume 36 (1991)

Volume 35 (1990)

Volume 34 (1989)

Volume 33 (1988)

Volume 32 (1987)

Volume 31 (1986)

Volume 30 (1985)

Volume 29 (1984)

Volume 28 (1983)

Volume 27 (1982)

Volume 26 (1981)

Volume 25 (1980)

Volume 24 (1979)

Volume 23 (1978)

Volume 22 (1977)

Volume 21 (1976)

Volume 20 (1975)

Volume 19 (1974)

Volume 18 (1973)

Volume 17 (1972)

Volume 16 (1971)

Volume 15 (1970)

Volume 14 (1969)

Volume 13 (1968)

Issue 1-6

Volume 12 (1967)

Issue 1-6

Volume 11 (1966)

Volume 10 (1965)

Issue 1-4

Volume 9 (1964)

Issue 1-4

Volume 8 (1963)

Volume 7 (1962)

Volume 6 (1961)

Volume 5 (1960)

Volume 4 (1959)

Volume 3 (1958)

Volume 2 (1957)

Volume 1 (1956)

5-year Impact Factor	1.382
Cite Score	3.2
Impact Factor	1.426
Journal Citation Indicator	0.34
SCImago Journal Rank	0.348
Source Normalized Impact per Paper	0.786

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Editorial

Editor-in-Chief
Jens Haueisen (Ilmenau, Germany)

Associate Editors
Peter Augat (Murnau, Germany)
Thomas Deserno (Braunschweig, Germany)
Steffen Leonhardt (Aachen, Germany)
Gernot Plank (Graz, Austria)
Klaus Radermacher (Aachen, Germany)
Erik Schkommodau (Muttenz, Switzerland)
Thomas Stieglitz (Freiburg, Germany)

Editorial Board
Ulrich Boenick (Berlin, Germany)
Olaf Dössel (Karlsruhe, Germany)
Pamela Habibovic (Maastricht, Netherlands)
Branislav Jaramaz (Pittsburgh, USA)
Marc Kraft (Berlin, Germany)
Thomas Lenarz (Hannover, Germany)
Harry van Lenthe (Leuven, Belgium)
Benny Lo (London, UK)
Luca Mainardi (Milano, Italy)
Silvestro Micera (Lausanne, Switzerland)
Thomas Penzel (Berlin, Germany)
Andrea Robitzki (Leipzig, Germany)
Klaus-Peter Schmitz (Rostock, Germany)
Tobias Schaeffter (London, UK)
Jess G. Snedeker (Zurich, Switzerland)
Leif Sörnmo (Lund, Sweden)
Nobuhiko Sugano (Osaka, Japan)
Jürgen Werner (Bochum, Germany)
Werner Wolf (Neubiberg, Germany)

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Genthiner Str. 13
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Tel. +49-30-26005-176
Fax: +49-30-26005-352
E-mail: bmt.editorial@degruyter.com

(Deutsch)

Online ISSN: 1862-278X
Print ISSN: 0013-5585
Type: Journal
Language: English
Publisher: De Gruyter
First published: January 1, 1956
Publication Frequency: 6 Issues per Year
Audience: researchers and decision-makers in the field of bioengineering, managers in development laboratories and in the entire sector of medical research, chief consultants in clinics, sanatoriums and hospitals, self-employed businesspeople and traders in the area of biomedical engineering, professionals in health insurance, libraries